Results 71 to 80 of about 184,262 (322)

Integration of BIM and Procedural Modeling Tools for Road Design

Infrastructures, 2020
Building Information Modeling (BIM) is a design and management methodology strongly used in the Industry of Architecture, Engineering, and Construction (AEC).
Salvatore Antonio Biancardo, Alessandra Capano, Sara Guerra de Oliveira, Andrej Tibaut   +3 more
doaj   +1 more source

From geometric design to numerical analysis: A direct approach using the Finite Cell Method on Constructive Solid Geometry

, 2017
During the last ten years, increasing efforts were made to improve and simplify the process from Computer Aided Design (CAD) modeling to a numerical simulation. It has been shown that the transition from one model to another, i.e.
Bog, Tino, Kollmannsberger, Stefan, Rank, Ernst, Wassermann, Benjamin   +3 more
core   +1 more source

PYCR1 inhibition in bone marrow stromal cells enhances bortezomib sensitivity in multiple myeloma cells by altering their metabolism

Molecular Oncology, EarlyView.
This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert, Lauren van den Broecke, Osman Aksoy, Judith Lind, Sonia Vallet, Arne Van der Vreken, Gamze Ates, Ann Massie, Ken Maes, Kim De Veirman, Elke De Bruyne, Karin Vanderkerken, Klaus Podar, Eline Menu   +13 more
wiley   +1 more source

Open-Data-Driven Unity Digital Twin Pipeline: Automatic Terrain and Building Generation with Unity-Native Evaluation

Applied Sciences
The creation of simulation-ready digital twins for real-world simulations is hindered by two key challenges: the lack of widely consistent, application-ready open access terrain data and the inadequacy of conventional evaluation metrics to predict ...
Donghyun Woo, Hyunbin Choi, Ruben D. Espejo Jr., Joongrock Kim, Sunjin Yu   +4 more
doaj   +1 more source

MODELS OF TRAINING PROCEDURES

Radio Electronics, Computer Science, Control, 2019
Context. The problem of justifying methods for constructing models of optimization procedures as dynamic objects, taking into account the features of the training procedures, is considered. The object of the study were models of the dynamics of training procedures. Objective.
Khodakov, V. Ye., Sokolov, A. Ye., Veselovskaya, G. V.   +2 more
openaire   +3 more sources

In vitro properties of patient serum predict clinical outcome after high dose rate brachytherapy of hepatocellular carcinoma

Molecular Oncology, EarlyView.
Following high dose rate brachytherapy (HDR‐BT) for hepatocellular carcinoma (HCC), patients were classified as responders and nonresponders. Post‐therapy serum induced increased BrdU incorporation and Cyclin E expression of Huh7 and HepG2 cells in nonresponders, but decreased levels in responders.
Lukas Salvermoser, Jan Niklas Schäfer, Shraga Nahum Goldberg, Philipp Maximilian Kazmierczak, Moritz Nikolaus Gröper, Philipp Franz Linden, Elif Öcal, Tanja Burkard, Stefanie Corradini, Najib Ben Khaled, Moritz Wildgruber, Max Seidensticker, Jens Ricke, Matthias Stechele, Marianna Alunni‐Fabbroni   +14 more
wiley   +1 more source

Introducing Java : the case for fundamentals-first [PDF]

, 2004
Java has increasingly become the language of choice for teaching introductory programming. In this paper, we examine the different approaches to teaching Java (Objects-first, Fundamentals-first and GUI-first) to ascertain whether there exists an agreed ...
Joy, Mike, Yau, Jane Yin-Kim
core  

Providing Self-Aware Systems with Reflexivity

, 2017
We propose a new type of self-aware systems inspired by ideas from higher-order theories of consciousness. First, we discussed the crucial distinction between introspection and reflexion.
A Church, A Damasio, A Valdemir, C Landauer, DP Friedman, F Peters, G Stein, G Trautteur, J Laird, J McCarthy, J McCarthy, J Torresen, JR Anderson, M Jammer, M Minsky, M Overgaard, MT Cox, PN Johnson-Laird, PR Lewis, R Sun, R Sun, R Weyhrauch   +21 more
core   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source