Results 51 to 60 of about 1,330,011 (333)
Imeglimin attenuates liver fibrosis by inhibiting vesicular ATP release from hepatic stellate cells
FEBS Letters, EarlyView.Imeglimin, at clinically relevant concentrations, inhibits vesicular ATP accumulation and release from hepatic stellate cells, thereby attenuating purinergic signaling and reducing fibrogenic activation. This mechanism reveals a newly identified antifibrotic action of imeglimin beyond glycemic control.
Seiji Nomura +8 more
wiley +1 more source
International Journal of Noncommunicable Diseases, 2017 With the view of rising burden of Noncommunicable diseases and the agenda to achieve Sustainable developmental goals, a professional organization working for NCDs globally World NCD Federation(WNF) and Post-Graduate Institute of Medical Education and ...
J S Thakur
doaj +1 more source
Cancer cell death induced by the NAD antimetabolite Vacor discloses the antitumor potential of SARM1
FEBS Letters, EarlyView.Vacor, a compound converted into the toxic metabolite Vacor adenine dinucleotide (VAD) by the nicotinamide salvage pathway enzymes NAMPT and NMNAT2, exhibits antitumor activity by inducing rapid and complete NAD depletion. We report that Vacor toxicity is limited to cell lines expressing high levels of SARM1, a NAD glycohydrolase.
Giuseppe Ranieri +5 more
wiley +1 more source
Društvene i Humanističke Studije, 2017 The studying of national history is important for building and affirming the identity of a country, people and society, but also the study of local history is important for the construction and promotion of the local identity and identity of the local ...
Semir Hadžimusić
doaj
PART B: 5th American Caribou Workshop, 19-21 March 1991, Yellowknife, Northwest Territories, Canada.
Rangifer, 1991 The 5th American Caribou Workshop was arranged at Yellowkife 1991 with 67 participants. The workshop addressed the issue of how ecological theory can be applied to practical caribou management problems.
Sven Skjenneberg (ed. in chief)
doaj +1 more source
Revealing the structure of land plant photosystem II: the journey from negative‐stain EM to cryo‐EM
FEBS Letters, EarlyView.Advances in cryo‐EM have revealed the detailed structure of Photosystem II, a key protein complex driving photosynthesis. This review traces the journey from early low‐resolution images to high‐resolution models, highlighting how these discoveries deepen our understanding of light harvesting and energy conversion in plants.
Roman Kouřil
wiley +1 more source
Valuation Category «Reasonable Time» in Civil Proceedings
Сибирское юридическое обозрение, 2016 The article is devoted to the category “reasonable time” in civil proceedings. The Author proves that the lack of a legal definition of “reasonable time” refers it to the valuation category that allows determining the reasonableness or unreasonableness ...
Yuliya E. Lemondjava
doaj +1 more source
Plasmodium falciparum gametogenesis essential protein 1 (GEP1) is a transmission‐blocking target
FEBS Letters, EarlyView.This study shows Plasmodium falciparum GEP1 is vital for activating sexual stages of malarial parasites even independently of a mosquito factor. Knockout parasites completely fail gamete formation even when a phosphodiesterase inhibitor is added. Two single‐nucleotide polymorphisms (V241L and S263P) are found in 12%–20% of field samples.
Frederik Huppertz +5 more
wiley +1 more source
8th North American Caribou Workshop, 20-24 April 1998, Whitehorse, Yukon, Canada.
Rangifer, 2000 Two hundred and forty people attended the 8th North American Caribou Workshop. Attendees brought perspectives from government and private sector research, management, industry, boards, councils and First Nations.
R.E. Haugerud (ed. in chief) +1 more
doaj +1 more source