Results 51 to 60 of about 21,239,949 (305)

Process-oriented integration in industrial information systems [PDF]

مجله مدل سازی در مهندسی, 2018
To cope with economic constraints, request for mass customization, globalization and cost reduction ... is increasingly enhanced and the development of manufacturing strategies towards a lean manufacturing strategy has gone. Lean strategy deployment in a
Sima Emadi, Najmeh Yavari
doaj   +1 more source

Process-oriented evaluation system for the use of robotic process automation

Proceedings of the Conference on Production Systems and Logistics, 2023
The administrative order processing is confronted with a variety of structural, procedural and organizational changes driven by the increasing demand for shorter delivery times and higher product variances.
Ortmeier, Christian, Langer, Adrian, Welzel, Kira, Abraham, Tim, Herrmann, Christoph, Herberger, David, Hübner, Marco, Stich, Volker   +7 more
doaj   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Bioremediation of Oriented Strand Board (OSB) Process Wastewater

BioResources, 2016
This study investigated the use of bioreactors and constructed wetlands to remediate oriented strand board (OSB) process wastewater. The first study evaluated the use of free cell bioreactors to reduce the biological oxygen demand (BOD).
L. Brad Stombock, Dragica Jeremic-Nikolic, Brian Baldwin, Hamid Borazjani, Susan V. Diehl   +4 more
doaj   +1 more source

A process model for collaboration in circular oriented innovation

Journal of Cleaner Production, 2020
Circular oriented innovation commonly requires collaboration. Yet, to date, circular research lacks empirical investigation into collaborative processes. Collaborative processes are, however, highly researched within strategic management literature, thus
P. Brown, C. Daniels, N. Bocken, A. Balkenende   +3 more
semanticscholar   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Process-oriented quality management [PDF]

, 2006
Quality management is a concept that has permanently grown up and been improved, and it integrates customer orientation, process orientation and quality orientation. Total Quality Management covers all the requirements of an Integrative Management concept. The revision and further development of the standard family ISO 9000:2000ff.
openaire   +4 more sources

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

FEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source

C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

FEBS Open Bio, EarlyView.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn, Barbara Seroka, Ryszard Lazny, Zenon Lotowski, Thore Rohwerder   +4 more
wiley   +1 more source