Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
Process Analytical Technology-Integrated FT-IR and Raman Spectroscopies for Efficient Reactive Liquid-Liquid Extraction Processing in Lithium Recycling. [PDF]
ACS OmegaUhl A, Humann AF, Schmidt A, Strube J.
europepmc +1 more source
PHARMA'S PROCESS ANALYTICAL TECHNOLOGY [PDF]
Chemical & Engineering News Archive, 2005 openaire +1 more source
Thermodynamic modeling of the no-vent fill methodology for transferring cryogens in low gravity [PDF]
The filling of tanks with cryogens in the low-gravity environment of space poses many technical challenges. Chief among these is the inability to vent only vapor from the tank as the filling proceeds.
Chato, David J.
core +1 more source
Effect of chemotherapy on passenger mutations in metastatic colorectal cancer
Molecular Oncology, EarlyView.Changes in passenger mutation load and predicted immunotherapy response after chemotherapy treatment. Tumor cells rich with passenger mutations have increased sensitivity to chemotherapy. Correlation of passenger mutations with neoantigen load suggests highly mutated clones promote a more effective response to immunotherapy, and therefore, first‐line ...
Marium T. Siddiqui +6 more
wiley +1 more source
Application of process analytical technology for real-time monitoring of synthetic co-culture bioprocesses. [PDF]
Anal Bioanal ChemDambruin NA, Pronk JT, Klijn ME.
europepmc +1 more source
Microalgae biorefinery symbiosis: screening, production, and process analytical technology [PDF]
, 2017 Podevin, Michael Paul Ambrose
core
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
Laser-based mid-IR photothermal spectroscopy of liquids: a new avenue for in-line sensing in process analytical technology. [PDF]
Anal Bioanal ChemKau-Wacht D +6 more
europepmc +1 more source