Results 121 to 130 of about 12,380,713 (296)

Computational Processes

Abstract This chapter draws a distinction between two types of computational process that mental representations can enter into. Content-specific transitions are transitions between representations that are faithful to representational content due to the specific non-logical concepts involved. Content-general transitions, e.g.
openaire   +2 more sources

Academic Cloud computing research : five pitfalls and five opportunities [PDF]

, 2015
Date of Acceptance: 25/04/2014This discussion paper argues that there are five fundamental pitfalls, which can restrict academics from conducting cloud computing research at the infrastructure level, which is currently where the vast majority of academic
Varghese, Blesson, Stuart Ward, Jonathan, Sommerville, Ian, Barker, Adam   +3 more
core   +1 more source

Consensus ensemble learning with augmented molecular representation for accelerated virtual screening of kelulut honey phytochemicals targeting histamine H1 receptor

Discover Molecules
Traditional antihistamine discovery has relied on experimental screening followed by stepwise structural optimization. However, this approach is effective yet low and resource-intensive.
Wei Feng Tan, Syajaratul Hassan, Raihana Edros, Suryanti Awang, RuiHai Dong   +4 more
doaj   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Towards a universal framework for heat pump monitoring at scale

Buildings & Cities
As heat pump installation across Europe increases, monitoring system performance on a large scale is key for policy decisions and customer confidence. However, in-situ heat pump monitoring has been found in previous work to be very challenging.
Jenny Crawley, Leon Domoney, Adam O’Donovan, Jez Wingfield, Cristian Dinu, Oliver Kinnane, Paul O’Sullivan   +6 more
doaj   +1 more source

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source

An Augmented Reality Application for an Immersive Laboratory Experience: The Zittau Flow Tray

ACC Journal
Integrating augmented reality (AR) into engineering education can enhance the learning experience for complex concepts. This study presents an AR application’s engineering process and prototype for the Zittau Flow Tray using (ZFT) Microsoft HoloLens 2 ...
González Morales Juan A., García Jorge Valle, Lindner Fabian, Zacharias Frank, Seeliger André   +4 more
doaj   +1 more source

Functional comparison of EncB and EncC cargo proteins in iron storage within the Myxococcus xanthus encapsulin

FEBS Letters, EarlyView.
Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell, Thomas Walther, Egbert Hoiczyk   +2 more
wiley   +1 more source

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source