Results 91 to 100 of about 12,020,127 (298)

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Methods for Rescuing People Using Climbing Equipment in Abandoned Mines to Be Carried Out by Rescue Units of the Integrated Rescue System

Safety
This article discusses the possibilities and methods for rescuing people from abandoned mine workings and the cooperation of the components of the Integrated Rescue System of the Slovak Republic when carrying out rescue work in underground spaces ...
Marek Szücs, Miroslav Betuš, Martin Konček, Marian Šofranko, Andrea Šofranková   +4 more
doaj   +1 more source

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source

Optimizing Emergency Response in Healthcare Facilities: Integration of Firefighting Technologies and Tactical Evacuation Strategies

Fire
This study analyzes the implementation of firefighting procedures and evacuation methods in a hospital environment, with a focus on ensuring rapid rescue operations and evacuation methods in a real fire in 2024.
Miroslav Betuš, Andrea Seňová, Annamária Behúnová, Ivanna Burachok, Galya Toteva Terzieva   +4 more
doaj   +1 more source

Wind Power Forecasting Using Multi-Objective Evolutionary Algorithms for Wavelet Neural Network-Optimized Prediction Intervals

Applied Sciences, 2018
The intermittency of renewable energy will increase the uncertainty of the power system, so it is necessary to predict the short-term wind power, after which the electrical power system can operate reliably and safely.
Yanxia Shen, Xu Wang, Jie Chen
doaj   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Bubbles Near a Vertical Wall: Experimental Investigation and Flow Analysis [PDF]

Journal of Applied Fluid Mechanics
The motion of bubbles near a solid vertical wall and the resulting induced flow field were experimentally investigated using the shadow method and particle image velocimetry (PIV).
R. Cai, J. Sun, W. Chen
doaj   +1 more source

On controlled Poisson processes

, 2014
Summary: We consider a special class of two-dimensional Markov processes, finding the relationship between transition probabilities of two such classes.
ALİYEV, T.m., IBAYEV, E.a., MAMEDOV, V.m.   +2 more
openaire   +3 more sources

UJI ALAT DINAMIKA PROSES DENGAN VARIABEL ORDE DUA NON INTERACTING (TEST THE DYNAMICS OF THE PROCESS TOOL WITH A SECOND ORDER NON-INTERACTING VARIABLES) [PDF]

, 2015
The dynamics of the process is something that occurs in a system, with the rapid process variables change with the opening control valve. On the dynamics of the process qualitatively capacity and delays are used as standard (size), while the transfer ...
BUDIANI, RIZKA AGUSTIN
core  

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source