Results 141 to 150 of about 4,885,236 (318)
Degradation mechanism of the von Willebrand factor A2 domain by nattokinase
FEBS Letters, EarlyView.Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto +3 more
wiley +1 more source
The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome
FEBS Letters, EarlyView.This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley +1 more source
FEBS Letters, EarlyView.An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley +1 more source
FEBS Letters, EarlyView.The physical dimensions and shape of bacterial cells define the surface area available to acquire nutrients and the volume available for synthesizing proteins and DNA. Here, we use computational systems biology to decode the importance of cell geometry as a major determinant of prokaryotic phenotype, including growth rate and metabolic efficiency. This
Ross P. Carlson +6 more
wiley +1 more source
, 2006 A hierarchical closed-loop production control scheme integrating scheduling, control and performance evaluation is discussed. Firstly, the production process is divided into two main hierarchies: the lower level is the physical operation level and the ...
Shi HB(史海波), Liu C(刘昶)
core
Automating Authority Control Procedures
, 2020 This paper is a part of the presentation, "Automating the Authority Control Process," for the Innovative Users Group Conference in 2020. The presentation introduces ideas on how to handle authority control using a variety of tools, both paid and free ...
Wolf, Stacey
core
Electron transfer between complexes III and IV in S. cerevisiae mitochondrial membranes
FEBS Letters, EarlyView.Mitochondrial oxidative phosphorylation in S. cerevisiae mitoplasts is limited by complex IV catalytic capacity, rather than two‐dimensional cytochrome c diffusion. At physiological cytochrome c : supercomplex ratios at salinity equivalent to that of 20 mm monovalent salt, activity is maximized, indicating that this low ionic strength accurately mimics
Ana Paula Lobez +2 more
wiley +1 more source
The rate of stable crack growth (SCG) in automotive steels sheets
Metalurgija, 2017 The main aim of this paper is determining the stable crack growth (SCG) rate for automotive steel sheets. The SCG was monitored using the non-contact videoextensometry technique.
Ľ. Ambriško, M. Cehlár, D. Marasová
doaj
Engineering Internship Final Report: Process Control Engineering
, 2010 In 2010, two final year students studying Instrumentation and Control Engineering at Murdoch University were given the opportunity to undertake a six month Process Control Engineering internship program at BHP Billiton’s Worsley Alumina Refinery located ...
Edwards, Kyle
core
FEBS Letters, EarlyView.We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace +6 more
wiley +1 more source