Results 151 to 160 of about 5,351,373 (348)

Sustainability - its incorporation into the mechanical engineering design process [PDF]

, 2014
Anthony Johnson
openalex  

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

Editorial: Integration and optimization in the chemical process industry

Frontiers in Chemical Engineering, 2022
Daniel Florez-Orrego, Daniel Florez-Orrego, Shivom Sharma, Seyed Navabi   +3 more
doaj   +1 more source

In the soft-to-hard technical spectrum: Where is software engineering? [PDF]

In the computer journals and tabloids, there have been a plethora of articles written about the software engineering field. But while advocates of the need for an engineering approach to software development, it is impressive how many authors have ...
Leibfried, Theodore F., Macdonald, Robert B.   +1 more
core   +1 more source

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

Integration of Genetic and Process Engineering for Optimized Rhamnolipid Production Using Pseudomonas putida. [PDF]

Front Bioeng Biotechnol, 2020
Tiso T, Ihling N, Kubicki S, Biselli A, Schonhoff A, Bator I, Thies S, Karmainski T, Kruth S, Willenbrink AL, Loeschcke A, Zapp P, Jupke A, Jaeger KE, Büchs J, Blank LM.   +15 more
europepmc   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Molecule Sensitive Optical Imaging and Monitoring Techniques-A Review of Applications in Micro-Process Engineering. [PDF]

Micromachines (Basel), 2020
Nachtmann M, Deuerling J, Rädle M.
europepmc   +1 more source

PURCHASING PROCESS ENGINEERING AS A FACTOR SHAPING THE QUALITY OF SERVICE

, 2013
Łukasz Marzantowicz
openalex   +1 more source

The importance of cost considerations in the systems engineering process [PDF]

This paper examines the question of cost, from the birth of a program to its conclusion, particularly from the point of view of large multi-center programs, and suggests how to avoid some of the traps and pitfalls.
Hodge, John D.
core   +1 more source