Results 241 to 250 of about 5,272,056 (327)

A CHALLENGING PROPOSAL OF DE FACTO STANDARD PROGRAM FOR DESIGN CLASS AND WORKSHOP ORIENTED TO THE ENVIRONMENTAL CONSCIOUS ARCHITECTURE BASED ON MCDM : Part1. An application in case of selecting process for dwellings(Environmental Engineering)

, 2003
Jun Tanimoto, Aya Hagishima
openalex   +2 more sources

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

Exploring the actual stacking height of metal powder bed in laser powder bed fusion additive manufacturing. [PDF]

Sci Rep
Lu P, Chen-Lin Z, Tong L, Jiang-Lin L, Heng-Hua Z, Mei Z.   +5 more
europepmc   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Control of immunogenic responses of microorganism-synthesized biopolymers for 3D bioprinting tissue engineering and regenerative medicine. [PDF]

Bioact Mater
Bhattacharyya A, Noh I.
europepmc   +1 more source

Transdisciplinary Engineering Design Process: Building a Common Design Network across Engineering Disciplines

, 2019
Mehwish Butt
openalex   +1 more source

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

Unlocking toughness in 3D-printed cement through bio-inspired designs: current status and future perspectives. [PDF]

RSC Adv
Fan L, Ji X, Wu C, Zhang W, Tong Y, Wang Q, Song F, Li F, Liu G, Li M.   +9 more
europepmc   +1 more source

Sustaining competencies and employability: A fishbone model for engineering education to fit the processes of life [PDF]

, 2019
Jay Somasundaram, M.G. Rasul, Pauline Danaher   +2 more
openalex  

Targeting p38α in cancer: challenges, opportunities, and emerging strategies

Molecular Oncology, EarlyView.
p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley   +1 more source