Results 191 to 200 of about 1,908,457 (313)

Simulation for Targeted Education, Process Improvement, and Systems Integration (STEPS): A Novel Approach to Health Care Quality Improvement Using In Situ Simulation. [PDF]

Jt Comm J Qual Patient Saf
Schoen JC, Klipfel JM, Wolfe SM, Willis VD, Torbenson VE, DeWitt JJ, Fang JL, Theiler RN.   +7 more
europepmc   +1 more source

A Plan to Transform Primary and Community Care at Catalonia based on a process improvement methodology

, 2023
Coll MS, Manjón S, Salabert J, Pladevall C, Algar D, Benaque A, Soler J, de Echagüen AO.   +7 more
europepmc   +1 more source

Implementing a Robust Process Improvement Program in the Neonatal Intensive Care Unit to Reduce Harm. [PDF]

J Healthc Qual, 2022
Nether KG, Thomas EJ, Khan A, Ottosen MJ, Yager L.   +4 more
europepmc   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Rational Utilization of Sugammadex Through Quantitative Twitch Monitoring: A Process Improvement Project at a Large Academic Medical Center. [PDF]

Cureus
Kowalsky M, Montejano J, Pattee J, Rist S, Fernandez-Bustamante A, Gilliland S, Weitzel N.   +6 more
europepmc   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

A plan to transform primary and community care at Catalonia based on a process improvement methodology. [PDF]

Prim Health Care Res Dev
Sales Coll M, Manjón S, Salabert J, Pladevall C, Algar D, Benaque A, Soler J, Ochoa de Echagüen Aguilar A.   +7 more
europepmc   +1 more source

Effect of an Emergency Department Process Improvement Package on Suicide Prevention: The ED-SAFE 2 Cluster Randomized Clinical Trial.

JAMA Psychiatry, 2023
Boudreaux ED, Larkin C, Vallejo Sefair A, Ma Y, Li YF, Ibrahim AF, Zeger W, Brown GK, Pelletier L, Miller I, ED-SAFE 2 Investigators.   +10 more
europepmc   +1 more source

Establishing a Reference Procedure Length for Anterior Cervical Fusions: The Role for Standards in Surgical Process Improvement. [PDF]

Cureus, 2022
Bohl M, Kakarla UK, Chang SW, Sethi R, Farrokhi F, Leveque JC.   +5 more
europepmc   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source