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A Depolarizing Leak in Sodium Bicarbonate Cotransporter NBCe1 Causes Brain Edema
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objectives SLC4A4 encodes electrogenic sodium bicarbonate cotransporter NBCe1, prominently expressed in kidney and brain. Recessive loss‐of‐function variants in SLC4A4 cause proximal renal tubular acidosis, no brain edema. In the brain, NBCe1 is expressed by astrocytes, where it regulates pH and mediates astrocyte volume changes.
Quinty Bisseling +16 more
wiley +1 more source
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From process integration to process intensification
Computers and Chemical Engineering, 2015Abstract In this paper, we establish a connection between process integration and process intensification. Focusing on processes with material recycle, we use an asymptotic analysis to demonstrate that intensification represents a limit case of tight integration through significant material recycling.
Michael Baldea
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Reviews in Chemical Engineering, 2017
AbstractProcess intensification (PI) is a rapidly growing field of research and industrial development that has already created many innovations in chemical process industry. PI is directed toward substantially smaller, cleaner, more energy-efficient technology. Furthermore, PI aims at safer and sustainable technological developments.
Anna Lee Tonkovich, Eric Daymo
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AbstractProcess intensification (PI) is a rapidly growing field of research and industrial development that has already created many innovations in chemical process industry. PI is directed toward substantially smaller, cleaner, more energy-efficient technology. Furthermore, PI aims at safer and sustainable technological developments.
Anna Lee Tonkovich, Eric Daymo
openaire +2 more sources
Process Intensification for Cellulosic Biorefineries
ChemSusChem, 2017AbstractUtilization of renewable carbon source, especially non‐food biomass is critical to address the climate change and future energy challenge. Current chemical and enzymatic processes for producing cellulosic sugars are multistep, and energy‐ and water‐intensive.
Sunitha, Sadula +4 more
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Process Intensification in Catalysis
2017Intensification of chemical (and/or physical) processes (PI) leads to higher efficiency in smaller equipment, better quality from more robust and flexible processes, as well as cost reduction with increased safety. These goals are very ambitious and need a complete toolbox of measures on all relevant length scales, from molecules to chemical plants ...
Sebastian Falß +2 more
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Process Intensification for Responsive Processing
Chemical Engineering Research and Design, 2002The era of responsive processing is upon us. It has emerged from the concepts of process intensi cation (PI) and is aimed towards the development of processes which are more responsive to market needs whilst responding to changes in process parameters in seconds or milliseconds rather than several minutes or hours, as is typi ed in a conventional ...
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Process Intensification: Industrial Applications
2016The chapter presents process intensification technologies used in industrial applications, for increasing the eco-efficiency of the chemical equipment with the benefit of lower capital costs, substantial energy saving, reduced footprint, and safety by design.
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Process intensification uses innovations in the design of equipment and processes to create more efficient, safer, and less wasteful chemical processes. Working on principles of avoiding unnecessary extras, reducing the size of set ups and tightly controlling reactions, there are benefits both in sustainability and in the economics of the processes.
Kamelia Boodhoo +5 more
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Kamelia Boodhoo +5 more
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