Results 111 to 120 of about 7,815,990 (296)

Results of expert judgments on the faults and risks with Autosub3 and an analysis of its campaign to Pine Island Bay, Antarctica, 2009 [PDF]

open access: yes, 2009
Probabilistic risk assessment is a methodology that can be systematically applied to estimate the risk associated with the design and operation of complex systems.
Brito, Mario P., Griffiths, Gwyn
core  

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

open access: yesMolecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat   +8 more
wiley   +1 more source

Proceedings of the Conference on Production Systems and Logistics : CPSL 2025

open access: yesProceedings of the Conference on Production Systems and Logistics
[no abstract available]
Herberger, David, Hübner, Marco
doaj   +1 more source

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

open access: yesMolecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli   +7 more
wiley   +1 more source

Development of an integrated and comprehensive clinical trial process management system. [PDF]

open access: yesBMC Med Inform Decis Mak, 2023
Shen L   +5 more
europepmc   +1 more source

Management of the technical training process of athletes in cycling sports [PDF]

open access: yes, 2019
In cyclic sports, the main indicator that characterizes adversarial activity is the average speed of passing distances. The presence of functional dependencies of speed factors on various indicators of sports activity can determine its dynamics.
Головач, Інна Іванівна   +3 more
core  

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

open access: yesMolecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley   +5 more
wiley   +1 more source

Design activity modelling : a performance viewpoint [PDF]

open access: yes, 2001
Design activity modelling has received significant attention in research over the last 30 years with a focus on both descriptive and prescriptive models.
Duffy, A.H.B., O'Donnell, F.J.
core  

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

open access: yesMolecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova   +25 more
wiley   +1 more source

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