Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante +10 more
wiley +1 more source
Gray matter volume moderates the effect of acute physical activity on cognitive load and relates to reading comprehension in adolescents: the Cogni-Action Project. [PDF]
Cristi-Montero C +10 more
europepmc +1 more source
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
Exploring Concepts of Understanding in the Working Practice of Speech and Language Therapists in the UK: A Preliminary Survey. [PDF]
Bunning K +4 more
europepmc +1 more source
Comprehension Models of Audiovisual Discourse Processing
Courtney Anderegg +3 more
openaire +2 more sources
Emerging experimental and computational methods for studying redox‐regulated structural transitions
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass +2 more
wiley +1 more source
Associations of Perceived Classical Chinese Text Reading Ability with Confucian Virtue Cognition and Practice Among Chinese Adolescents: The Indirect Role of Internalization Experience. [PDF]
Shen L, Wu B, Yuan B.
europepmc +1 more source
A Comprehensive Static Model for COREX Process
Qu, Yingxia, Zou, Zongshu, Xiao, Yanping
openaire +2 more sources
Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança +2 more
wiley +1 more source
Reading comprehension self-efficacy and mathematical problem-solving in primary education: a serial mediation model through mathematical reasoning and critical thinking. [PDF]
Filiz T, Kaplan K.
europepmc +1 more source

