Results 191 to 200 of about 120,243 (299)

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Standardising written informed consent forms to improve patient care: a quality improvement project. [PDF]

BMJ Open Qual
Akram J, Jasim N, Al Hattab F, Khalid M, Jebril RA, Alsheikh IS, Bougaila A, Elamin NH, Subhash E, Tawengi MM, Zahid M.   +10 more
europepmc   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Memory-Based or Experience-Based? Subject-Object Asymmetry in Mandarin Relative Clause Processing from the Aging Perspective. [PDF]

Behav Sci (Basel)
Liu X, Shi J, Wu S.
europepmc   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Discourse type effects on EFL listening comprehension: cognitive load and metacognitive strategy shifts across scientific and literary texts. [PDF]

BMC Psychol
Mekheimer M.
europepmc   +1 more source

A comprehensive model of the electroslag remelting process

, 2008
Le procédé de refusion sous laitier électroconducteur (Electro Slag Remelting ou ESR) est aujourd'hui largement utilisé pour la production d'alliages métalliques à haute valeur ajoutée, comme les aciers spéciaux ou les superalliages base nickel. La modélisation mathématique et la simulation numérique du procédé ESR présentent un grand intérêt puisque ...
openaire   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Large Language Model-Based Simplification of Digital Therapeutics Explanations for Insomnia and Nicotine Dependence: Two Randomized Online Experiments. [PDF]

JMIR Hum Factors
Seo J, Yook M, Kim DJ, Lee J, Yoo JH, Byeon G, Choi IY.   +6 more
europepmc   +1 more source