Results 131 to 140 of about 25,160,792 (332)
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Maximizing Foundation Effectiveness: Aligning Program Strategy, Organizational Capacity, Strategic Planning, and Performance Assessment to Achieve Success [PDF]
, 2008 This paper outlines a framework for increasing the philanthropic performance of an organization by focusing on strategic planning and development of tight logic models for the organization's programs.
Paul Connolly
core
LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro
Molecular Oncology, EarlyView.Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix +13 more
wiley +1 more source
The acceptance process in road planning [PDF]
, 2005 This paper presents a case study of the dialogue between the road department and the general public during the early stages of two Swedish road projects. The two road projects were located in Skåne in southern Sweden.
Hylmö, Kajsa
core
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
Plan in progress: a critique of the selective coproduction of the Spatial Policy Plan for Flanders (Belgium) [PDF]
, 2013 In recent years, so-called coproductive, radical strategic planning has become a synonym for integrative and holistic public sector-led planning processes and the alleged integrating qualities of representative democracies.
Boelens, Luuk, Boussauw, Kobe
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Redox regulation meets metabolism: targeting PRDX2 to prevent hepatocellular carcinoma
Molecular Oncology, EarlyView.PRDX2 acts as a central redox hub linking metabolic dysfunction‐associated steatohepatitis (MASH) to hepatocellular carcinoma (HCC). In normal hepatocytes, PRDX2 maintains redox balance and metabolic homeostasis under oxidative stress. In contrast, during malignant transformation, PRDX2 promotes oncogenic signaling, stemness, and tumor initiation ...
Naroa Goikoetxea‐Usandizaga +2 more
wiley +1 more source
A planning language for activity scheduling [PDF]
Mission planning and scheduling of spacecraft operations are becoming more complex at NASA. Described here are a mission planning process; a robust, flexible planning language for spacecraft and payload operations; and a software scheduling system that ...
Lavallee, David +3 more
core +1 more source
, 2015 The word plan is in English both a verb and a noun, reminding us that to plan is a process resulting in a product, a plan. While the Last Planner System (LPS) is primarily focused on how to plan and control production, other planning concepts are more
Aslesen, Sigmund +2 more
core
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source