Results 91 to 100 of about 18,891,728 (302)
Frontiers in Microbiology, 2019 Aspergillus ochraceus is reported to be the major contributor of ochratoxin A (OTA), classified as one of the possible human carcinogen (group 2B) by the International Agency for Research on Cancer.
Gang Wang +9 more
doaj +1 more source
Organoids in pediatric cancer research
FEBS Letters, EarlyView.Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley +1 more source
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
What makes a good process model? Lessons learned from process mining
, 2012 There seems to be a never ending stream of new process modeling notations. Some of these notations are foundational and have been around for decades (e.g., Petri nets).
Aalst, WMP Wil van der +2 more
core +1 more source
Synthesis of High-Quality Libraries of Long (150 mer) Oligonucleotides by a Novel Depurination Controlled Process [PDF]
, 2010 We have achieved the ability to synthesize thousands of unique, long oligonucleotides (150mers) in fmol amounts using parallel synthesis of DNA on microarrays.
Caruthers, Marvin H. +6 more
core +1 more source
Proceedings of the Conference on Production Systems and LogisticsPerformance measurement and especially the evaluation of products and processes in terms of their quality is crucial for every company. Due to globalization and outsourcing activities, manufacturing depth decreases resulting in a value chain spread over ...
Meyer, Maurice +4 more
doaj +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Discovering and navigating a collection of process models using multiple quality dimensions
, 2014 Process discovery algorithms typically aim at discovering a process model from an event log that best describes the recorded behavior. However, multiple quality dimensions can be used to evaluate a process model.
Song, M. +5 more
core +1 more source
Process-oriented quality management [PDF]
, 2006 Quality management is a concept that has permanently grown up and been improved, and it integrates customer orientation, process orientation and quality orientation. Total Quality Management covers all the requirements of an Integrative Management concept. The revision and further development of the standard family ISO 9000:2000ff.
openaire +4 more sources
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source