Results 251 to 260 of about 1,960,973 (310)

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma

Molecular Oncology, EarlyView.
Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski, Júlia Perera‐Bel, Alejo Rodriguez‐Vida, Nuria Juanpere, Jihyun Lee, Daniel E. Michaud, Jennifer L. Guerriero, Kent W. Mouw, Aristotelis Bamias, Filipe L. F. Carvalho, Joaquim Bellmunt   +10 more
wiley   +1 more source

Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis

Molecular Oncology, EarlyView.
This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht, Sameer Gupta, Amrita Chaurasia, Manisha Sachan   +3 more
wiley   +1 more source

Weakening the nuclear envelope: Lamin B receptor in melanoma metastasis

Molecular Oncology, EarlyView.
LBR‐driven nuclear fragility supports melanoma invasion. A: Melanocyte presents low LBR (Lamin B Receptor) levels, maintaining nuclear integrity and lamina‐chromatin tethering. B: During malignant progression, upregulation of LBR clusters at the INM (Inner Nuclear Membrane) during confined migration causes local lamina weakening and cholesterol ...
Francesca Lorenzini, Maria Caterina Mione   +1 more
wiley   +1 more source

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

Molecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski, Liudmyla Dolinchuk, Michał Jerzak, Albert Gandurski, Tomasz Grochowski, Weronika Wojtyś, Maciej Zadrożny, Wojciech Kaźmierczak, Małgorzata Lenarcik, Marta Matejak‐Górska, Radosław Samsel, Tomasz Olesiński, Dawid Walerych   +12 more
wiley   +1 more source

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Process and Process Variables

2018
This chapter covers the concepts of process, process design and operation, and process variables. Process parameters herein include mole, density, specific gravity, specific volume, flow rate, fraction, concentration, temperature, pressure, and other thermodynamic properties of the materials.
Seyed Ali Ashrafizadeh, Zhongchao Tan
openaire   +1 more source

Analyzing variability in continuous processes

European Journal of Operational Research, 2004
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Kumar Rajaram, Andreas Robotis
openaire   +1 more source

RENEWAL PROCESS FOR FUZZY VARIABLES

International Journal of Uncertainty, Fuzziness and Knowledge-Based Systems, 2007
Recently, Zhao and Liu [IJUFKS 11 (2003) 573–586] proposed a "fuzzy elementary renewal theorem" and "fuzzy renewal rewards theorem" for a renewal process in which the inter-arrival times and rewards are characterized as continuous fuzzy variables. The continuity assumption is restrictive.
openaire   +2 more sources

Variables estimation in autogeneous processes

Automation and Remote Control, 2013
Variables of an autogeneous process are described. The suggested processing technique for experimental data gives a practical interpretation to the obtained results. Finally, a method of defining probabilistic relationships between different variables of the object is proposed.
E. D. Kadyrov, N. V. Danilova
openaire   +1 more source

Monitoring Process Variability for Stationary Process Data

Quality and Reliability Engineering International, 2014
Processes that arise naturally, for example, from manufacturing or the environment, often exhibit complicated autocorrelation structures. When monitoring such a process for changes in variance, accounting for that structure is critical. While charts for monitoring the variance of processes of independent observations and some specific autocorrelated ...
Nien Fan Zhang, Adam L. Pintar
openaire   +1 more source