Results 71 to 80 of about 6,728,003 (316)

ORGANIZATIONAL HR PROCESSES IN COMPLIANCE WITH THE QUALITY MANAGEMENT SYSTEM [PDF]

Business Excellence and Management
The main aim of the article is to present practical examples of HR practices with respect to the quality management system and its standards. A bibliometric analysis was conducted to obtain an overview of research trends in the field of HR management in ...
Natália VRAŇAKOVÁ, Zdenka GYURÁK BABEĽOVÁ   +1 more
doaj   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Identifying and Prioritizing the Indicators Influencing the Performance of the Permit-to-work System Using Hybrid Fuzzy Delphi Method - Improve Analytic Hierarchy Process Methods: An Exploratory Cross-sectional Study

International Journal of Environmental Health Engineering
Aim: This study aimed to identify and prioritize the main indicators that influence the performance of the permit-to-work (PTW) using hybrid fuzzy Delphi-improve analytic hierarchy process (IAHP) methods. Materials and Methods: By the fuzzy Delphi method,
Seyed Mahdi Mousavi, Saeid Yazdanirad, Seyed Abolfazl Zakerian, Ali Karimi   +3 more
doaj   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

SPATIAL-TENPORAL CHARACTERISTICS OF INNOVATIVE DEVELOPMENT INSTITUTIONS

Вестник университета, 2019
Spatial and temporal characteristics of the institutions in general, and innovative development in particular are determined primarily by the research objectives, which correspond to different interpretations of the institutions as objects, environments,
B. Yerznkyan
doaj  

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Mechanisms of IgE‐mediated food allergy and the role of allergen‐specific B cells

FEBS Letters, EarlyView.
Food allergy arises when allergen‐specific B cells preferentially produce immunoglobulin E (IgE) antibodies against harmless foods. This article explains the mechanisms driving IgE‐mediated reactions, highlights the central role of these B cells, and discusses how natural tolerance (NT) and oral immunotherapy (OIT) can reshape allergic immune responses.
Juan‐Felipe López, Özge Yilmaz Ardicli, Mübeccel Akdis   +2 more
wiley   +1 more source

Sustainability and Governance in Developing Open Source Projects as Processes of In-Becoming [PDF]

Technology Innovation Management Review, 2013
Sustainability is often thought of as a binary state: an open source project is either sustainable or not. In reality, sustainability is much more complex. What makes this project more sustainable than that one?
Daniel Curto-Millet
doaj