Results 161 to 170 of about 370 (219)

Mutation type‐specific transcriptomic signatures and readthrough therapy rescue in SMC1A‐related developmental and epileptic encephalopathy

Epilepsia, EarlyView.
Abstract Objective This study was undertaken to investigate the molecular consequences of pathogenic variants in the SMC1A gene—particularly those associated with developmental and epileptic encephalopathy (DEE85)—and to evaluate the therapeutic potential of ataluren in restoring SMC1A function and mitigating disease‐related transcriptomic and genomic ...
Maddalena Di Nardo, Francesca Sardina, Maria M. Pallotta, Iñigo Marcos‐Alcalde, Paulino Gómez‐Puertas, Cinzia Rinaldo, Ian D. Krantz, Antonio Musio   +7 more
wiley   +1 more source

Tunable PhenoCycler imaging of the murine pre-clinical tumour microenvironments. [PDF]

Cell Biosci
Abraham MJ, Goncalves C, McCallum P, Gupta V, Preston SEJ, Huang F, Chou H, Gagnon N, Johnson NA, Miller WH, Mann KK, Del Rincon SV.   +11 more
europepmc   +1 more source

Full‐scale Shaking Table Tests on a 10‐story Steel Moment‐resisting Frame Building with Buckling‐restrained Braces

Earthquake Engineering &Structural Dynamics, EarlyView.
ABSTRACT In February 2023, a comprehensive series of shaking table tests were conducted at the E‐Defense facility, the world's largest three‐dimensional earthquake simulator, on a full‐scale 10‐story steel moment‐resisting frame supplemented with BRBs.
Jun Fujiwara, Jialiang Jin, Jionghui Li, Tianhao Yan, Ryota Nishi, Akiko Kishida, Koichi Kajiwara, Takuya Nagae, Taichiro Okazaki, Tatsuya Asai   +9 more
wiley   +1 more source

Local climate, air quality and leaf litter cover shape foliar fungal communities on an urban tree. [PDF]

Ambio
Faticov M, Amorim JH, Abdelfattah A, van Dijk LJA, Carvalho AC, Laforest-Lapointe I, Tack AJM.   +6 more
europepmc   +1 more source

Individual variability and versatility in an eco-evolutionary model of avian migration. [PDF]

Proc Biol Sci, 2020
Delmore KE, Van Doren BM, Conway GJ, Curk T, Garrido-Garduño T, Germain RR, Hasselmann T, Hiemer D, van der Jeugd HP, Justen H, Lugo Ramos JS, Maggini I, Meyer BS, Phillips RJ, Remisiewicz M, Roberts GCM, Sheldon BC, Vogl W, Liedvogel M.   +18 more
europepmc   +1 more source

Inconsistent Transcriptomic Responses to Hexabromocyclododecane in Japanese Quail: A Comparative Analysis of Results From Four Different Study Designs

Environmental Toxicology and Chemistry, EarlyView.
Abstract Efforts to use transcriptomics for toxicity testing have classically relied on the assumption that chemicals consistently produce characteristic transcriptomic signatures that are reflective of their mechanism of action. However, the degree to which transcriptomic responses are conserved across different test methodologies has seldom been ...
Paul Béziers, Elena Legrand, Emily Boulanger, Niladri Basu, Jessica D. Ewald, Paula Henry, Markus Hecker, Jianguo Xia, Natalie Karouna‐Renier, Doug Crump, Jessica Head   +10 more
wiley   +1 more source

ImmuNet: a segmentation-free machine learning pipeline for immune landscape phenotyping in tumors by multiplex imaging. [PDF]

Biol Methods Protoc
Sultan S, Gorris MAJ, Martynova E, van der Woude LL, Buytenhuijs F, van Wilpe S, Verrijp K, Figdor CG, de Vries IJM, Textor J.   +9 more
europepmc   +1 more source

Proteomic signatures of equine dental tooth tissues in ageing and disease

Equine Veterinary Journal, EarlyView.
Abstract Background Ageing and dental disease in horses lead to structural and functional deterioration of dental tissues, yet their molecular signatures remain poorly characterised. Understanding how these processes alter the protein composition of enamel, dentin, cementum and pulp is essential for improving equine oral health and identifying ...
Anders Jensen, Danae Emilie Zambouli, Iris Gringel, Zoe Nugent, Kazuhiro Yamamoto, Lee Cooper, Andrew J. Peffers, Guido Rocchigiani, Mandy J. Peffers   +8 more
wiley   +1 more source

Molecular Palaeontology Prospects From Exceptionally Preserved Eocene Brackish‐Water Bivalve Batissa sitakaraensis (Venerida: Corbiculidae) From Hokkaido, Japan

Geological Journal, EarlyView.
This study reports the exceptional preservation of the Eocene freshwater bivalve Batissa sitakaraensis from Hokkaido, Japan. Multimodal analyses reveal that both the aragonitic shell mineralogy and the delicate organic periostracum retain their original structural and chemical characteristics after millions of years.
Taro Yoshimura, Kazuki Hirota, Hiroyuki Kagi, Takashi Matsubara, Takenori Sasaki   +4 more
wiley   +1 more source

Hemp Extract (Extractum Cannabis) in the Treatment of Gastrointestinal Distress and Dyspepsia: Historical Insights from Barcelona, Spain. [PDF]

Pharmaceuticals (Basel)
Riboulet-Zemouli K, Allué Creus J.
europepmc   +1 more source