Results 41 to 50 of about 370 (219)

Cuproptosis and Mitophagy Mediated by the THUMPD1/IGF2R‐Dependent Suppression of AKT and Activation of AMPK Signaling Suppress Lung Adenocarcinoma Progression

Advanced Science, EarlyView.
THUMPD1 drives a tumor‐suppressive signaling cascade in lung adenocarcinoma by promoting IGF2R expression. IGF2R associates with PPP2R1A to suppress AKT and activate AMPK, leading to SLC31A1 upregulation and copper accumulation. Elevated copper disrupts mitochondrial metabolism and induces excessive mitophagy, thereby restraining tumor growth and ...
Kai Wu, Bo Qin, Zhuoyu Gu, Weizheng Ding, Xiaoming Chen, Kaishang Zhang, Yujin Qiao, Shuang Yuan, Song Zhao, Xiangnan Li, Peng Zhang   +10 more
wiley   +1 more source

„ARCHIVES OF VELA LUKA“ – THE PROJECT OF COLLECTING AND PROCESSING OF THE WHOLE ARCHIVAL MEMORY ON THE LOCAL LEVEL

, 2011
U tekstu autor nastoji dati pregled arhivističke djelatnosti Općine Vela Luka u razdoblju od 2006. do 2011. Navode se aktivnosti u prikupljanju, sređivanju i obradi, opisu, digitalizaciji i web prezentaciji gradiva.
Barčot, Tonko, Tonko Barčot
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Extracellular Vesicle‐Transferred ATP‐Citrate Lyase Induces Monocyte Differentiation Toward Tumor‐Associated Macrophages and Fuels Hepatocellular Carcinoma Progression

Advanced Science, EarlyView.
Hepatocellular carcinoma (HCC)‐derived extracellular vesicles (EVs) enrich the metabolic enzyme ATP‐citrate lyase (ACLY). EV‐transferred ACLY enhances palmitate biosynthesis, increases the S‐palmitoylation and stability of multiple immune checkpoint proteins, augments the cellular immunosuppressive activity, and ultimately accelerates the malignant ...
Zhijun Liu, Haihong Lai, Qing Yang, Chaoyue Zhang, Bin Jia, Qiyi Chen, Yuling Deng, Fen Cao, Yuyu You, Zhe Li, Dongming Kuang, Bo Li   +11 more
wiley   +1 more source

Single‐Cell Dissection of Tumor‐Infiltrating Lymphocytes Reveals Cellular Architecture Predictive of Therapeutic Efficacy in Acral Melanoma

Advanced Science, EarlyView.
Autologous tumor‐infiltrating lymphocyte (TIL) therapy shows promising efficacy in acral melanoma, yet determinants of durable response remain unclear. By integrating single‐cell transcriptomics and TCR sequencing, this study reveals that TIL products enriched for T follicular helper and intermediate exhausted T cells establish persistent clonal ...
Chao Zhang, Wanyi Xiao, Hongru Shen, Fenge Li, Ting Li, Weihong Zhang, Haotian Liu, Ziwei Gao, Hongyu Wang, Xiubao Ren, Kexin Chen, Xiangchun Li, Jilong Yang   +12 more
wiley   +1 more source

Simpson Family fonds

, 1905
This digital collection consists of photographs relating to a succession of sawmills and wood processing and manufacturing facilities founded and operated by Stanley Merriam Simpson in the Okanagan region.

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El tractament arxivístic dels fons d'artistes. Una aplicació pràctica : l'Estudi Pilarín Bayés [PDF]

, 2016
El tema d'estudi d'aquest treball de recerca és la reflexió sobre l'aplicació del tractament arxivístic als fons documentals d'artistes a partir de la cerca bibliogràfica i la investigació portada a terme a l'Estudi Pilarín Bayés.
Universitat Autònoma de Barcelona. Escola Superior d'Arxivística i Gestió de Documents, García López, Sara   +1 more
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Prikupljanje, obrada i korištenje arhivskoga gradiva 9. (kninskog) korpusa Jugoslavenske narodne armije u Hrvatskom memorijalno-dokumentacijskom centru Domovinskog rata u Zagrebu

, 2019
The Croatian Memorial Documentation Center of Homeland War in Zagreb stores archival fonds of the 9th (Knin’s) Corps of the Yugoslav People’s Army, the total of fifty eight boxes (5,8 linear meters) of archives, confiscated by the Croatian forces after ...
Brigović, Ivan, Caričić, Josipa, Ivan Brigović, Josipa Caričić   +3 more
core   +1 more source

DNA Replication Errors Drive Genome‐Wide Small Inverted Triplication Dynamics

Advanced Science, EarlyView.
This study provides insight into the dynamic equilibrium mechanism of a novel structural variant, small inverted triplication (SIT), which is generated by misalignment of the 3’ flap generated under DNA replication stress with palindromic sequence. Alternatively, the end sequence may fold back on itself to form an inverted fragment.
Yi Lei, Yu Zhou, Haitao Sun, Hang Yuan, Xinyu Pei, Jessica D. Hess, Yao Yan, Zunsong Hu, Mian Zhou, Zhaohui Gu, Li Zheng, Xiwei Wu, Binghui Shen   +12 more
wiley   +1 more source

El tractament arxivístic dels fons personals de científics

, 2021
La primera part d'aquest treball està dedicada a la caracterització dels fons personals de científics, analitzant-los com a fons personals d'una banda i com a fons de ciència de l'altra.
Terreu Gascón, Miquel, Fernández Trabal, Josep (Dir)   +1 more
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MFPD: A Multiple Fungal Pathogen Detection Pipeline Across Diverse Habitats

Advanced Science, EarlyView.
The MFPD pipeline integrates a comprehensive ITS reference database of fungal pathogens, optimized parameters, and algorithms tailored for both full‐length and subregion sequences that balance accuracy and computational efficiency; it enables high‐throughput, species‐level identification from amplicon sequencing data, supporting large‐scale ...
Yi Shen, Xinrun Yang, Jiabao Yu, Yaozhong Zhang, Tianjie Yang, Yang Gao, Xiaofang Wang, Alexandre Jousset, Waseem Raza, Fang‐Jie Zhao, Qirong Shen, Gaofei Jiang, Zhong Wei, Yangchun Xu   +13 more
wiley   +1 more source