Results 121 to 130 of about 189,936 (358)

Public procurement trajectories in Tanzania: a review of reforms, practices, and compliance

Cogent Business & Management
Over decades, public procurement in Tanzania experienced critical reforms; however, not much is known about the reforms and hence there is a dearth of comprehensive reviews about them.
Alban D. Mchopa, Ismail Abdi Changalima, Gabriel R. Sulle, Rahim M. Msofe   +3 more
doaj   +1 more source

Targeting UXS1‐Dependent Glucuronate Detoxification Potentiates Metformin's Anti‐Tumor Efficacy in Lung Adenocarcinoma

Advanced Science, EarlyView.
This study reveals that metformin promotes glucuronic acid metabolism in lung adenocarcinoma by activating UGDH S476 phosphorylation and enhancing the conversion of UDPG to UDPGA based on metabolomics analysis. Through compound virtual screening, it is found that plantainoside targeting UGDH downstream UXS1 leads to UDPGA toxicity accumulation ...
Qihai Sui, Zhencong Chen, Guangyao Shan, Zhengyang Hu, Xing Jin, Jiaqi Liang, Yanjun Yi, Jiacheng Yin, Haochun Shi, Xifei Jiang, Junjie Xi, Zongwu Lin, Cheng Zhan, Fenghao Sun, Wei Jiang   +14 more
wiley   +1 more source

Mechanostimulatory Cues Determine Intestinal Fibroblast Fate and Profibrotic Remodeling in a Physiodynamic Human Gut‐on‐a‐Chip

Advanced Science, EarlyView.
A healthy gut barrier shields underlying fibroblasts from luminal shear forces, illustrating that “good fences make good neighbors.” Barrier damage exposes fibroblasts to shear stress, inducing cell death and the emergence of stress‐adapted, profibrotic fibroblasts. Sustained shear exposure promotes the formation of stiff aggregates of mechanoadapative
Soyoun Min, Nam Than, Yong Cheol Shin, Elif G. Ertugral, Chandrasekhar R. Kothapalli, Olumuyiwa Awoniyi, Hyun Jung Kim   +6 more
wiley   +1 more source

Harmonising procurement policy environment - identifying key themes towards the development of a conceptual model [PDF]

, 2006
Capital works procurement and its regulatory policy environment within a country\ud can be complex entities. For example, by virtue of Australia’s governmental division between\ud the Commonwealth, states and local jurisdictions and the associated ...
London, Kerry (R19003), Purcell, S., London , Kerry, Purcell, Shaun, Bellamy, Thomas, Bellamy, T., London, Kerry   +6 more
core  

The impact of level of documentation on the accessibility and affordability of new drugs in Norway

Frontiers in Pharmacology
Introduction: Over the preceding decade, an increasing number of drugs have been approved by the European Medicines Agency (EMA) with limited knowledge of their relative efficacy.
Gro Live Fagereng, Gro Live Fagereng, Anne Marit Morvik, Sara Reinvik Ulimoen, Sara Reinvik Ulimoen, Sara Reinvik Ulimoen, Anne Marthe Ringerud, Iselin Dahlen Syversen, Erik Sagdahl, Erik Sagdahl   +9 more
doaj   +1 more source

Adipocyte‐Derived Leptolin Enhances Energy Expenditure and Prevents Obesity

Advanced Science, EarlyView.
We identified a novel adipokine, which we named leptolin. In humans, leptolin levels in white adipose tissue were positively correlated with exercise and negatively associated with body mass index. We observed elevated leptolin in serum from athletes and lower leptolin in serum from obese individuals.
Jiarui Liu, Bingwei Wang, Zhijie Su, Xiaoxv Han, Miao He, Yun Zhao, Yujia Hou, Daotong Li, Weiguang Zhang, Lihua Qin, Ke Wang, Yanchun Li, Yi Yan, Siwang Yu, Xiaoshuai Huang, Tairan Yuwen, Jianyuan Luo, Ruimao Zheng   +17 more
wiley   +1 more source

The impact of procurement methods on delivering environmentally sensitive buildings

, 2007
In the UK, new building regulations (‘Part L2006’) to reduce energy consumption and carbon dioxide emissions within the built environment came into force in 2006.
Greenwood, David, Hamza, Neveen
core  

The Role of Quality Performance Metrics on Improving Procurement Effectiveness: A Case of Higher Education Students’ Loans Board, Tanzania

International Journal of Business, Economics, and Social Development
Procurement effectiveness for public sector is triggered by the fact that, performance measurements determine the extent of improvement in relation to the outputs and the efforts made.
Getrude John Danieli, Justus Justard Justinian   +1 more
doaj   +1 more source

Effect of Speculators’ Position Changes on the LME Futures Market

International Journal of Financial Studies, 2019
This paper employs Granger causality tests to analyze the role of speculators using weekly COTR (commitment of traders reports) data covering the period of August 2014 to July 2017.
Jaehwan Park
doaj   +1 more source

RNA Helicase DDX21 Controls CD4+ T Cell Proliferation and Promotes Inflammatory Bowel Disease via Translational Control

Advanced Science, EarlyView.
ABSTRACT Inflammatory bowel disease (IBD) is characterized by dysregulated T cell responses. RNA helicases, including DExD‐box helicase 21 (DDX21), are pivotal in RNA metabolism, but their role in T cell‐mediated pathology during IBD remains unclear. Here, we demonstrate that DDX21 expression in CD4+ T cells correlates with cell cycle and translation ...
Yujuan Zhang, Chen Kan, Xinhui Yang, Yajuan Hao, Xuemin Cai, Mei Yang, Qianqian Zhang, Zhengting Wang, Ning Jiang, Lei Wang, Hua‐Bing Li, Jing Zhou   +11 more
wiley   +1 more source