Results 171 to 180 of about 289,430 (341)

A Universal Toughening and Energy‐Dissipating Strategy for Impact‐Resistant 3D‐Printed Composites

open access: yesAdvanced Science, EarlyView.
A universal toughening and energy dissipation strategy inspired by B─O bonds, which can significantly enhance the mechanical properties of composites, enables 3D‐printed smart impact‐resistant structures. Abstract 3D‐printed polymer‐based composites are promising for various engineering applications due to high strength‐to‐weight ratios and design ...
Xiang Hong   +6 more
wiley   +1 more source

Building the capacity of Sierra Leoneans in supply chain on the National Pharmaceutical Procurement Unit (NPPU) project (a case study)

open access: yesJournal of Pharmaceutical Policy and Practice, 2014
Maurice Juma   +2 more
doaj   +1 more source

PP1A Modulates the Efficacy of Lenvatinib Plus ICIs Therapy by Inhibiting Ferroptosis in Hepatocellular Carcinoma

open access: yesAdvanced Science, EarlyView.
PP1A dephosphorylates Keap1 at the S104 site, stabilizing and promoting the nuclear translocation of Nrf2, which upregulates the expression of antioxidant genes and PD‐L1. This leads to suppressed ferroptosis and enhanced immune evasion, thereby improving the efficacy of TKI and ICI combination therapy.
Jitong Zhou   +10 more
wiley   +1 more source

The GRK2/AP‐1 Signaling Axis Mediates Vascular Endothelial Dysfunction and Atherosclerosis Induced by Oscillatory Low Shear Stress

open access: yesAdvanced Science, EarlyView.
This study highlights GRK2 is a central mediator in OSS‐induced endothelial dysfunction. OSS activates GPCRs in endothelial cells, leading to GRK2 phosphorylation and the activation of AP‐1. AP‐1 induces inflammation, while also promoting NR4A1 expression and anchoring LKB1 in the nucleus, which suppresses AMPK activity. This cascade causes endothelial
Li‐Da Wu   +18 more
wiley   +1 more source

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