Advanced Science, EarlyView.This study develops a cartilage‐targeted DNA origami system (OCS) that protects and delivers si‐Stat3 to chondrocytes. OCS reduces MMP13 expression, enhances extracellular matrix stability, and lowers oxidative stress while improving cell survival. In vivo, OCS decreases cartilage degradation biomarkers and promotes tissue repair factors, demonstrating
Qi Lv +8 more
wiley +1 more source
Evaluation of changes in price, volume and expenditure of PD-1 drugs following the government reimbursement negotiation in China: a multiple-treatment period interrupted time series analysis. [PDF]
J Glob HealthYi H +7 more
europepmc +1 more source
International Book Procurement; or, Farmington Extended
, 1960 Robert Vosper
openalex +2 more sources
Advanced Science, EarlyView.Akkermansia depletion correlates with acute pancreatitis (AP) severity. A. muciniphila and its protein Amuc_1409 mitigate pancreatic/systemic inflammation by expanding Tregs and IL‐10. Mechanistically, Amuc_1409 binds Ube2k, inhibiting Foxp3 ubiquitination to stabilize Treg differentiation and IL‐10 production, countering SAP‐induced SIRS/CARS ...
Jinyan Xie +9 more
wiley +1 more source
Government regulation or market mechanism? A study on the collaborative innovation pathways of the emergency industry based on evolutionary game models. [PDF]
PLoS OneZhang X, Li H, Kang Q, Chen L.
europepmc +1 more source
Proposed Gas Turbine Procurement Standard [PDF]
, 1972 J. J. Broderick, J. C. Nelsen
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A Wearable AI‐Driven Mask with Humidity‐Sensing Respiratory Microphone for Non‐Vocal Communication
Advanced Science, EarlyView.A wearable, plug‐and‐play respiratory microphone—featuring a gold nanoparticle‐based humidity sensor—facilitates voice‐free verbal communication for patients with impaired vocal fold function. Abstract Hoarseness and dysphonia caused by vocal cord conditions or laryngeal surgeries significantly hinder communication and quality of life.
Jianfei Wang +8 more
wiley +1 more source
Strengthening TB laboratory systems: addressing diagnostic and systemic barriers in drug-resistant TB. [PDF]
Public Health ActionJung JK, Quelapio M, Cho SN.
europepmc +1 more source
Functional approach to turnkey system procurement [PDF]
, 1975 Wayne Churchman
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Microbial Biosensor for Sensing and Treatment of Intestinal Inflammation
Advanced Science, EarlyView.The engineered calprotectin biosensor detects gut inflammation, processes the signal through genetic regulation, and responds by expressing the reporter sfGFP and the therapeutic protein secIL10. This dual functionality enables the engineered biosensor not only to sense but also to mitigate gut inflammation, highlighting its potential for disease ...
Duolong Zhu +8 more
wiley +1 more source