Results 31 to 40 of about 85,062 (229)

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

Order management practices and small-scale grape processing firms’ performance: the moderating effect of logistics capabilities

African Business Management Journal
This study examines the moderating effect of logistics capabilities on the relationship between order management practices and the performance of small-scale grapes processing firms.
Debora Chelestino Kisinga, Alban Dismas Mchopa, Leonada Raphael Mwagike   +2 more
doaj   +1 more source

Overview of molecular signatures of senescence and associated resources: pros and cons

FEBS Open Bio, EarlyView.
Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas, Sylvia Vagena, Pavlos Pantelis, Giorgos Theocharous, Russel Petty, Konstantinos Evangelou, Vassilis G. Gorgoulis   +6 more
wiley   +1 more source

The role of lipid metabolism in neuronal senescence

FEBS Open Bio, EarlyView.
Disrupted lipid metabolism, through alterations in lipid species or lipid droplet accumulation, can drive neuronal senescence. However, lipid dyshomeostasis can also occur alongside neuronal senescence, further amplifying tissue damage. Delineating how lipid‐induced senescence emerges in neurons and glial cells, and how it contributes to ageing and ...
Dikaia Tsagkari, Eleftheria Panagiotidou, Nektarios Tavernarakis   +2 more
wiley   +1 more source

Procurement skills and procurement performance in public organizations: The mediating role of procurement planning

Cogent Business & Management, 2023
Skills are important qualities that procurement practitioners should have because they are relevant to procurement activities. Given its significance, this study investigates the influence of procurement skills on procurement performance in public ...
Ismail Abdi Changalima, Anjela Ewald Mdee   +1 more
doaj   +1 more source

Characterization of Clinical Phenotype to Glial Fibrillary Acidic Protein Concentrations in Alexander Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To determine the concentration of glial fibrillary acidic protein (GFAP) in cerebrospinal fluid (CSF) and plasma in Alexander disease (AxD) and whether GFAP levels are predictive of disease phenotypes. Methods CSF and plasma were collected (longitudinally when available) from AxD participants and non‐AxD controls.
Amy T. Waldman, Asako Takanohashi, Joshua Y. Joung, Geraldine W. Liu, Kaley Arnold, Amy Pizzino, Walter Faig, Sarah Woidill, Sona Narula, Adeline L. Vanderver   +9 more
wiley   +1 more source

Deterministic Application of Process-centric Law to the System-centric Requirements of Procurement Procedures

Potchefstroom Electronic Law Journal, 2021
South Africa's public procurement system is accorded constitutional status, establishing fundamental requirements for the operation of the system. The application of these constitutional system requirements and their interpretation in the judicial ...
David John Wickens
doaj   +1 more source

A Concept of a Digital and Traceable Manufacturing Documentation Based on Formalized Process Description Applied on Composite Aircraft Moveable

Advanced Engineering Materials, EarlyView.
The documentation of component manufacture has become an essential part of today's production processes, especially for the analysis and optimization of production or component design with regard to structural performance, economic efficiency, and sustainability.
Björn Denker, Dominik Delisle, Christian Krombholz, Martin Rädel, Frank Dressel   +4 more
wiley   +1 more source

The interplay between green supply chain management practices and firm performance: does green technological innovation and institutional pressure matter? [PDF]

Journal of Responsible Production and Consumption
PurposeThis study aims to investigate the impact of green supply chain management practices on firm performance and the intervening roles of green technological innovation and institutional pressures in this relationship.Design/methodology/approachThis ...
Alexander Otchere Fianko, Daniel Etse, Meshach Awuah-Gyawu, Darlington Bright Yao Adanfo   +3 more
doaj   +1 more source

Inter-organisational communication: organisational future orientation, inter-organisational interaction quality and inter-organisational group mechanism

Journal of International Humanitarian Action, 2022
The purpose of this study is to investigate the effect of organisational future orientation and interaction quality on inter-organisational communication, and the mediating role of inter-organisational group mechanism on the relationship between ...
Henry Mutebi, Mose Muhwezi, Joseph M. Ntayi, John C. Munene   +3 more
doaj   +1 more source