Epicatechin induces NF-kappa B, activator rotein-1 (AP-1) and nuclear transcription factor erythroid 2p45-related factor-2 (Nrf2) via phosphatidylinositol-3-kinase/protein kinase B (PI3K/AKT) and extracellular regulated kinase (ERK) signalling in HepG2 cells [PDF]
The dietary flavonoid epicatechin has been reported to exhibit a wide range of biological activities. The objective of the present study was to investigate the time-dependent regulation by epicatechin on the activity of the main transcription factors (NF-
Bravo, Laura +5 more
core +4 more sources
Abstract BACKGROUND Peanut skin, a byproduct of peanut processing, is a rich source of phenolic compounds (520.65 mgGAE (100 g)−1 d.b.) with strong antioxidant capacity, but which remains underutilized. The direct incorporation of phenolic extracts into dairy products is challenging, due to their instability during processing and storage and possible ...
Ana Carolina Tucumantel Ribeiro +7 more
wiley +1 more source
Pyrogallol Structure in Polyphenols is Involved in Apoptosis-induction on HEK293T and K562 Cells
As multiple mechanisms account for polyphenol-induced cytotoxicity, the development of structure-activity relationships (SARs) may facilitate research on cancer therapy.
Akiko Saito +4 more
doaj +1 more source
Isothiocyanates as Ferroptosis Inducers to Promote Cancer Cell Death
ABSTRACT Cancer remains a leading cause of global mortality, with the therapeutic efficacy of anticancer drugs often hampered by late diagnosis and the development of chemotherapy resistance. Ferroptosis is an iron‐dependent form of regulated non‐apoptotic cell death driven by lipid peroxidation.
Valentina Citi +6 more
wiley +1 more source
Abstract This study examined whether consuming a (poly)phenol‐rich food before strenuous muscle‐damaging exercise can modify post‐exercise markers of inflammation and oxidative stress. Using a double‐blinded, randomised, placebo‐controlled, between‐subjects design, 26 recreationally active males (n = 15) and females (n = 11) consumed higher‐(poly ...
Abrar Al Hebshi +5 more
wiley +1 more source
Chronic inflammatory diseases such as diabetic wounds and osteoarthritis are significant threats to human health. Failure to scavenge longstanding excessive reactive oxygen species (ROS) is an important cause of chronic inflammatory diseases, yet ...
Linxiao Sun +6 more
doaj +1 more source
The Study of Main Physical-chemical Parameters of Chaenomeles and Products of Its Processing [PDF]
In the article were considered the topical problems, connected with health worsening and human existence. The use of vegetable raw material as a source of biologically active components is prospective in production foodstuff.
Boroday, A. (Anzhela) +4 more
core +2 more sources
ABSTRACT Rationale Bioactive (E)‐stilbenoids in vine extracts are prone to light‐induced transformation into the respective (Z)‐isomers and further degradation products, often resulting in a loss of bioactivity. We sought to study stilbenoid degradation beyond that of the well‐researched resveratrol due to the high diversity of stilbenoids in nature ...
Paul Besrukow +3 more
wiley +1 more source
Processing and storage effects on the polyphenolic content and antioxidant capacity of conventional and sugar-free blueberry jams [PDF]
Fresh blueberries have received much attention due to their positive role in human health and disease prevention. The abundance of polyphenolics, namely anthocyanins and procyanidins, is thought to play an important role in health promotion.
Brownmiller, Cindi +2 more
core +2 more sources
Anthelmintic activity of trans-cinnamaldehyde and A- and B-type proanthocyanidins derived from cinnamon (Cinnamomum verum) [PDF]
Cinnamon (Cinnamomum verum) has been shown to have anti-inflammatory and antimicrobial properties, but effects on parasitic worms of the intestine have not been investigated. Here, extracts of cinnamon bark were shown to have potent in vitro anthelmintic
A Gazzinelli +45 more
core +2 more sources

