Results 1 to 10 of about 47,573 (142)

Clinical characteristics and risk factors of depression in prodromal Parkinson’s disease [PDF]

Frontiers in Neuroscience
BackgroundDepression is a highly prevalent non-motor symptom in Parkinson’s disease (PD) that can manifest several years prior to the clinical diagnosis of PD.
Jianxia Xu, Yali Wang, Yuqian Li, Hui Wang, Weiguo Liu   +4 more
doaj   +2 more sources

Editorial: Prodromal Parkinson's Disease [PDF]

Frontiers in Neurology, 2021
David Crosiers, David Crosiers, Patrick Santens, K. Ray Chaudhuri   +3 more
doaj   +5 more sources

Association of Peripheral Blood Neutrophil‐Lymphocyte Ratio With Motor and Cognitive Function in Prodromal Parkinson's Disease [PDF]

Brain and Behavior
Introduction Neutrophil and lymphocyte levels and their ratio, the neutrophil‐lymphocyte ratio (NLR), in the peripheral blood provide accessible indices of systemic inflammatory activity. In this study, we evaluated whether these blood markers are linked
Jin‐Sun Jun, Nyeonju Kang, Kyeongho Byun, Kiwon Park, Ryul Kim   +4 more
doaj   +2 more sources

Longitudinal assessment of DNA repair signature trajectory in prodromal versus established Parkinson’s disease [PDF]

npj Parkinson's Disease
Parkinson’s disease (PD) is a progressive neurodegenerative disorder. DNA repair dysfunction and integrated stress response (ISR) dysregulation have been implicated in PD pathophysiology, however, their role during the prodromal phase remains unclear. We
Danish Anwer, Nicola Pietro Montaldo, Elva Maria Novoa-del-Toro, Diana Domanska, Hilde Loge Nilsen, Annikka Polster   +5 more
doaj   +2 more sources

Prodromal dreams

Frontiers in Psychiatry
I present a provisional model and promising evidence, pending robust longitudinal validation, for the possibility of prodromal dreams: dreams that predict onset of illness before overt symptoms appear.
Patrick McNamara, Patrick McNamara
doaj   +3 more sources

Prodromal stage of late-onset psychosis

European Psychiatry, 2022
Introduction Prodromal stage of psychosis may be an aim of prevention first episode psychosis. In late-onset psychosis it’s low described. Objectives The aim of this investigation is to describe prodromal phase of late-onset psychosis and their ...
V. Pochueva, V. Sheshenin, M. Savina, T. Safarova   +3 more
doaj   +1 more source

Early Detection of Ultra High Risk for Psychosis in a Norwegian Catchment Area: The Two Year Follow-Up of the Prevention of Psychosis Study

Frontiers in Psychiatry, 2021
Objectives: Most individuals experience a relatively long period of sub-clinical psychotic like symptoms, known as the ultra high risk (UHR) or at risk mental states (ARMS), prior to a first episode of psychosis. Approximately 95% of individuals who will
Inge Joa, Inge Joa, Jone Bjornestad, Jone Bjornestad, Jone Bjornestad, Jan Olav Johannessen, Jan Olav Johannessen, Johannes Langeveld, Johannes Langeveld, Helen J. Stain, Helen J. Stain, Melissa Weibell, Melissa Weibell, Wenche ten Velden Hegelstad, Wenche ten Velden Hegelstad   +14 more
doaj   +1 more source

Increased Asymmetric Perfusion of the Cerebral Cortices and Thalamus Indicates Individuals at Risk for Bipolar Disorder: A Family Cohort Single Photon Emission Computed Tomography Neuroimaging Study

Frontiers in Psychiatry, 2022
Bipolar disorder is a significant mental illness affecting over 4 million people in North America and approximately 46 million worldwide. While the onset of bipolar disorder is typically in late adolescence and early adulthood, the correct diagnosis can ...
Mary McLean, Mary McLean, Theodore A. Henderson, Theodore A. Henderson, Theodore A. Henderson, Theodore A. Henderson, Theodore A. Henderson, Dan G. Pavel, Dan G. Pavel, Phil Cohen, Phil Cohen, Phil Cohen   +11 more
doaj   +1 more source

A Guide to the Generation of a 6-Hydroxydopamine Mouse Model of Parkinson’s Disease for the Study of Non-Motor Symptoms

Biomedicines, 2021
In Parkinson’s disease (PD), a large number of symptoms affecting the peripheral and central nervous system precede, develop in parallel to, the cardinal motor symptoms of the disease.
Débora Masini, Carina Plewnia, Maëlle Bertho, Nicolas Scalbert, Vittorio Caggiano, Gilberto Fisone   +5 more
doaj   +1 more source

Baseline measures of cerebral glutamate and GABA levels in individuals at ultrahigh risk for psychosis: Implications for clinical outcome after 12 months

European Psychiatry, 2020
Background.Cerebral glutamate and gamma-aminobutyric acid (GABA) levels might predict clinical outcome in individuals at ultrahigh risk (UHR) for psychosis but have previously primarily been investigated in smaller cohorts.
C. Wenneberg, B. Y. Glenthøj, L. B. Glenthøj, B. Fagerlund, K. Krakauer, T. D. Kristensen, C. Hjorthøj, R. A. E. Edden, B. V. Broberg, K. B. Bojesen, E. Rostrup, M. Nordentoft   +11 more
doaj   +1 more source