After 4 weeks of antidepressant treatment, patients with serum amyloid β oligomers showed a significantly lower treatment response compared with those without Aβ oligomers among middle‐aged and late‐life patients with major depressive disorder. ABSTRACT Aim Late‐life patients with depression are reportedly less responsive to antidepressant treatment ...
Kentaro Shimizu +4 more
wiley +1 more source
Incidence and clinical manifestations of sudden death in young adults: a two-decade, nationwide, retrospective, cross-sectional study. [PDF]
Maayan Y +12 more
europepmc +1 more source
Low Sensitivity of Neuropsychological Scales Hinder Detection of Potential Benefit of Treatments in Alzheimer's Disease: A Position Paper. [PDF]
ABSTRACT Background Despite the advent of Disease Modifying Therapies (DMTs) for Alzheimer's Disease (AD), the approval and commercialization of anti‐amyloid monoclonal antibodies has been slow and contentious, particularly in Europe. The primary source of debate is the discrepancy between robust biological effects—namely, effective β‐amyloid clearance—
Luzzi S, Snowden JS.
europepmc +2 more sources
rTCT: Rodent Triangle Completion Task to Facilitate Reverse Translational Study of Path Integration
ABSTRACT Path integration is navigation in the absence of environmental landmarks and is a primary cognitive mechanism underlying spatial memory. Path integration performance is primarily assessed in humans using the Triangle Completion Task (TCT). In humans, TCT has shown promise for the early diagnosis of Alzheimer's disease.
Stephen Duncan +13 more
wiley +1 more source
Clinical features, prognostic factors of pediatric acute necrotizing encephalopathy: a 67-case retrospective analysis. [PDF]
He Y +7 more
europepmc +1 more source
Fingerprints Encode Risk for Bipolarity
ABSTRACT Background Fingerprint patterns are developed during pregnancy and share a common embryogenic origin with the central nervous system. Considering the observed relationship between prenatal abnormalities and higher risk for schizophrenia, we previously built fingerprint‐based algorithms achieving validation accuracies up to 70% in a large ...
Raymond Salvador +25 more
wiley +1 more source
Sleep in Early Psychosis and Bipolar Disorder: Preliminary Results on Actigraphic and Self-Reported Markers of Vulnerability. [PDF]
Baldini V +9 more
europepmc +1 more source
Abstract Background The distribution pattern of central tarsal bone (CTB) changes has not been described, except for slab‐ and dorsomedial–plantarolateral fractures. Objectives To describe CTB changes in CT and document their distribution and associations. Study Design Retrospective case series.
Sandra Campana +3 more
wiley +1 more source
Abstract INTRODUCTION Sleep and circadian disturbances are early Alzheimer's disease (AD) features, yet mechanisms linking amyloid pathology, neuroinflammation, and sex differences remain unclear. METHODS We longitudinally assessed sleep, circadian rhythms, and cognition in female and male hAPPSAA knock‐in and control mice from 2 to 19 months using ...
Teresa Macheda +18 more
wiley +1 more source
Translation, validation, predictive analysis of the Italian version of the McSweeney Acute and Prodromal Myocardial Infarction Symptom Survey and symptom cluster characterization in women. [PDF]
Giordano V +6 more
europepmc +1 more source

