Results 141 to 150 of about 47,670 (237)

Associations between sleep disturbance and cerebrospinal fluid Aβ, and shared proteomic signatures in Alzheimer's disease

Alzheimer's &Dementia, Volume 22, Issue 4, April 2026.
Abstract INTRODUCTION Sleep disturbance is increasingly recognized as a risk factor for Alzheimer's disease (AD), but longitudinal clinical evidence linking sleep behaviors to cerebrospinal fluid (CSF) amyloid beta (Aβ) dynamics and related proteomic signatures remains limited.
Tianbai Li, Meichen Liu, Peng Zhang, Song Li, Tao Qiu, Xinhui Qiu, Bo Sun, Huaibin Cai, Cong Liu, Junliang Yuan, Weidong Le, Alzheimer's Disease Neuroimaging Initiative   +11 more
wiley   +1 more source

Interactions between blood pressure variability, cerebral autoregulation, and covert cerebral small vessel disease in relation to cognitive performance in community‐dwelling older adults

Alzheimer's &Dementia, Volume 22, Issue 4, April 2026.
Abstract INTRODUCTION Both increased blood pressure variability (BPV) and impaired cerebral autoregulation (CA) have been linked to cerebral small vessel disease (CSVD) and cognitive performance, but whether they independently or interactively influence cognition remains unclear. METHODS We analyzed 300 community‐dwelling participants. Dynamic CA, beat‐
Nai‐Fang Chi, Li‐Ning Peng, Chun‐Jen Lin, Hao‐Min Cheng, Chen‐Huan Chen, Pei‐Ning Wang, Chih‐Ping Chung   +6 more
wiley   +1 more source

MultimodalCNN-PD: a Parkinson's disease diagnostics framework using multimodal convolutional neural network. [PDF]

Front Aging Neurosci
Zhi T, Liu H, Wang X, Ibrahim UM, Meng C.   +4 more
europepmc   +1 more source

Amyotrophic Lateral Sclerosis and Frontotemporal Dementia Have Distinct Prediagnostic Blood Biochemical Profiles

Annals of Neurology, Volume 99, Issue 4, Page 844-856, April 2026.
Objective Identifying modifiable factors influencing amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) risk is important for prevention. Blood biomarkers, particularly cholesterol, have been associated with neurodegenerative risk, but findings in ALS are inconsistent, and data on FTD are limited.
Christos V. Chalitsios, Jiali Gao, Carol A.C. Coupland, Julia Hippisley Cox, Martin R. Turner, Alexander G. Thompson   +5 more
wiley   +1 more source

Cerebrospinal fluid dopamine 3-O-sulfate as a novel biomarker for predicting motor complications in Parkinson's disease: insights from the PPMI cohort. [PDF]

J Transl Med
Chi J, Yang R, Zhang P, Rong S, Cai M, Zhang Y.   +5 more
europepmc   +1 more source

Serum p‐tau217 Is a Prognostic Indicator of Cognitive Impairment in Idiopathic REM Sleep Behavior Disorder

Annals of Neurology, Volume 99, Issue 4, Page 912-921, April 2026.
Objective Assess the performance of serum phosphorylated tau 217 (p‐tau217) and neurofilament light chain (NfL) in predicting risk of cognitive impairment or phenoconversion to dementia in individuals with iRBD. Methods We measured serum p‐tau217 and NfL levels by electrochemiluminescence across 4 polysomnographically confirmed iRBD cohorts (n = 300 ...
Shijun Yan, Anis Sahoo, Tanja Zerenner, Kenneth Marek, Michael Sommerauer, Wolfgang Oertel, Michele T. Hu, George K. Tofaris   +7 more
wiley   +1 more source

Adherence to the Mediterranean and Mediterranean‐Dietary Approaches to Stop Hypertension Intervention for Neurodegenerative Delay (MIND) Diets and Parkinson's Disease Incidence in Women: Results from the Prospective E3N Cohort

Annals of Neurology, Volume 99, Issue 4, Page 1014-1029, April 2026.
Objective The evidence regarding adherence to dietary patterns and Parkinson's disease (PD) risk is inconsistent. Because of the long prodromal PD phase, reverse causation represents a major threat to investigations of diet in relation to PD. We examined whether adherence to the Mediterranean (MED) and Mediterranean‐Dietary Approaches to Stop ...
Mariem Hajji‐Louati, Emmanuelle Correia, Pei‐Chen Lee, Fanny Artaud, Emmanuel Roze, Francesca Romana Mancini, Alexis Elbaz   +6 more
wiley   +1 more source

Correlating symptoms and skin α-synuclein seeding parameters in olfactory dysfunction and Lewy body dementia. [PDF]

J Neurol
McWilliam OH, Bsoul R, Areškevičiūtė A, Andersen ISB, Bruun M, von Buchwald C, Hasselbalch SG, Lund EL, Pedersen CK, Simonsen AH, Waldemar G, Aanæs K, Frederiksen KS.   +12 more
europepmc   +1 more source

Speech Biomarkers From Smartphone Calls Track Progression in REM Sleep Behavior Disorder and Parkinson's Disease

Annals of Neurology, Volume 99, Issue 4, Page 935-948, April 2026.
Objective This 24‐month longitudinal study involving isolated rapid eye movement sleep behavior disorder (iRBD), early‐stage Parkinson's disease (PD), and matched healthy control subjects aimed to assess whether acoustic speech features from real‐world smartphone calls provide passive progressive biomarkers in synucleinopathies.
Michal Šimek, Tereza Tykalová, Michal Novotný, Vojtěch Illner, Tomáš Kouba, Martin Šubert, Pavel Sovka, Jan Švihlík, Evžen Růžička, Karel Šonka, Petr Dušek, Jan Rusz   +11 more
wiley   +1 more source

Atypical Guillain‐Barré Syndrome Preceding Icteric Hepatitis A: A Diagnostic Challenge—A Case Report

Clinical Case Reports, Volume 14, Issue 4, April 2026.
ABSTRACT Guillain–Barré syndrome (GBS) is an acute immune‐mediated neuropathy typically triggered by infections. Rarely, it may precede acute hepatitis A (HAV), creating diagnostic challenges. We report a 32‐year‐old male presenting with ascending weakness and tingling in limbs without initial hepatic symptoms.
Asem Afana, Ahmed H. Sharaf, Jana Omar, Ahmad Elkhazin, Hossam Salameh   +4 more
wiley   +1 more source