Results 161 to 170 of about 47,670 (237)

Non-Motor Symptoms as Markers of Disease Severity in Parkinson's Disease: Associations Between Constipation, Depression, REM Sleep Behavior Disorder, and Motor Impairment. [PDF]

Biomedicines
Mota Telles JP, Labello JH, Camargo L, Pastora-Sesin C, Gianlorenço AC, Fregni F.   +5 more
europepmc   +1 more source

Elevated prodromal psychotic symptoms lead to impaired social functioning via loneliness: A longitudinal mediation study. [PDF]

Soc Psychiatry Psychiatr Epidemiol
Marcham L, Richardson T, Kelley NJ, Ellett L.   +3 more
europepmc   +1 more source

Therapeutic Impact of Caffeic Acid Phenethyl Ester and Acyclovir Combination on Human Gingival Fibroblasts (HGF‐1) Infected With Herpes Simplex Type 1 ICP0

MicrobiologyOpen, Volume 15, Issue 2, April 2026.
ABSTRACT Herpes simplex virus Type 1 (HSV‐1) is a prevalent infectious agent globally, often causing oral infections like gingivostomatitis. The ICP0 protein of HSV‐1 exacerbates infection severity by inhibiting antiviral responses. Our study explored how combinations of CAPE (caffeic acid phenethyl ester) and acyclovir influenced immune responses in ...
Merve Sen, Sefa Celik
wiley   +1 more source

Cholinergic degeneration in prodromal and early Parkinson's disease: a link to present and future disease states. [PDF]

Brain
Eisenstein T, Groenewald K, van Hillegondsberg L, Al Hajraf F, Zerenner T, Lawton MA, Ben-Shlomo Y, Griffanti L, Hu MT, Klein JC.   +9 more
europepmc   +1 more source

Unraveling Chronic Pain: From Mechanisms and Risks to Diagnosis and Treatment

MedComm, Volume 7, Issue 4, April 2026.
Chronic pain arises through distinct molecular pathways categorized into nociceptive, neuropathic, and nociplastic types. Nociceptive pain begins with TRP channel activation in peripheral nociceptors, signaling via Aδ‐ and C‐fibers through the spinal dorsal horn and spinothalamic tracts to the brain, regulated by descending inhibition and involving ...
Xiaofeng Dai, Chongxiang Wang, Ping Jiang, Xiaopeng Mei   +3 more
wiley   +1 more source

Cancer Neuroscience: Innovative Conception and Emerging Strategy of Therapy

MedComm, Volume 7, Issue 4, April 2026.
In this review, we summarize nerve–cancer interactions and conclude two additional interactions, “perineural invasion” and “neuro‐microbic‐oncology.” Emphasizing the important role of nerves in tumor progression. The nervous system also contributes to the development of cancer comorbidities such as cancer depression and cognitive dysfunction.
Ting Wang, Zikai Dong, Yongfei Wang, Ziyi An, Siyuan Wang, Wei‐Lin Jin   +5 more
wiley   +1 more source

Duration of Untreated Eating Disorder and Prodrome in Young People: Characteristics and Relationship to Early Outcomes. [PDF]

Early Interv Psychiatry
McClelland J, Austin A, Flynn M, Mountford VA, Simic M, Schmidt U.   +5 more
europepmc   +1 more source

Antihypertensive medications and risk of Alzheimer's disease: Evidence for specific medication use

Alzheimer's &Dementia: Translational Research &Clinical Interventions, Volume 12, Issue 2, April/June 2026.
Abstract BACKGROUND Hypertension is a modifiable risk factor for Alzheimer's disease (AD). Specific antihypertensive classes may lower/increase AD risk by affecting the renin–angiotensin–aldosterone system. METHODS We investigated AD risk in relation to antihypertensive medications in a population‐based study of 33,714 incident AD cases and 897,872 ...
Osvaldo J. Laurido‐Soto, Alejandra Camacho‐Soto, Irene M. Faust, Kassu M. Beyene, Aaron J. Katz, Jordan A. Killion, Brad A. Racette   +6 more
wiley   +1 more source

Exposure to Antipsychotics in Youths at Clinical High Risk for Psychosis: Low VS High Doses and Their Relevance for Clinical Outcomes

Early Intervention in Psychiatry, Volume 20, Issue 4, April 2026.
ABSTRACT Introduction Predicting prognosis in subjects at Clinical High Risk for Psychosis (CHR‐P) is still challenging. In particular, there are some disregarded factors such as ongoing Antipsychotic (AP) treatment that potentially induce method errors and research bias.
Lorenzo Pelizza, Emanuela Leuci, Emanuela Quattrone, Alessandro Di Lisi, Derna Palmisano, Simona Pupo, Giuseppina Paulillo, Clara Pellegrini, Pietro Pellegrini, Marco Menchetti   +9 more
wiley   +1 more source

Epigenetic ageing and the risk of Parkinson's disease. [PDF]

J Neurol Neurosurg Psychiatry
Peng X, Flores-Torres MH, Cortese M, Peng C, Hung AY, Schwarzschild M, Ascherio A, Bjornevik K.   +7 more
europepmc   +1 more source