Results 11 to 20 of about 47,670 (237)

Longitudinal evaluation of olfactory function in individuals with Gaucher disease and GBA1 mutation carriers with and without Parkinson's disease

Frontiers in Neurology, 2022
ObjectiveBiallelic mutations in GBA1, which encodes the lysosomal enzyme glucocerebrosidase, cause the lysosomal storage disorder Gaucher disease (GD).
Grisel J. Lopez, Jens Lichtenberg, Nahid Tayebi, Emory Ryan, Abigail L. Lecker, Ellen Sidransky   +5 more
doaj   +1 more source

A review of current evidence for mild behavioral impairment as an early potential novel marker of Alzheimer’s disease

Frontiers in Psychiatry, 2023
Mild behavioral impairment (MBI) is a neurobehavioral syndrome that occurs in the absence of cognitive impairment later in life (≥50 years of age). MBI is widespread in the pre-dementia stage and is closely associated with the progression of cognitive ...
Piaopiao Jin, Jiaxi Xu, Zhengluan Liao, Yuhan Zhang, Ye Wang, Wangdi Sun, Enyan Yu   +6 more
doaj   +1 more source

Methodological Issues in Randomized Clinical Trials for Prodromal Alzheimer's and Parkinson's Disease

Frontiers in Neurology, 2021
Alzheimer's disease (AD) and Parkinson's disease (PD) are the first and second most common neurodegenerative disorders, respectively. Both are proteinopathies with inexorable courses and no approved disease-modifying therapies.
Camila Henriques de Aquino, Camila Henriques de Aquino, Camila Henriques de Aquino   +2 more
doaj   +1 more source

The prodromal microbiome [PDF]

Movement Disorders, 2017
Non peer ...
openaire   +3 more sources

Serum miR-214 Serves as a Biomarker for Prodromal Parkinson’s Disease

Frontiers in Aging Neuroscience, 2021
Circulating microRNAs (miRNAs) have been proposed to be accessible biomarkers for Parkinson’s disease (PD). However, there is a lack of known miRNAs that can serve as biomarkers for prodromal PD (pPD).
Lanting Li, Jingru Ren, Chenxi Pan, Yuqian Li, Jianxia Xu, Hui Dong, Yong Chen, Weiguo Liu   +7 more
doaj   +1 more source

Sleep Spindles and Fragmented Sleep as Prodromal Markers in a Preclinical Model of LRRK2-G2019S Parkinson's Disease

Frontiers in Neurology, 2020
Sleep disturbances co-occur with and precede the onset of motor symptoms in Parkinson's disease (PD). We evaluated sleep fragmentation and thalamocortical sleep spindles in mice expressing the p.G2019S mutation of the leucine-rich repeat kinase 2 (LRRK2)
Lindsey M. Crown, Mitchell J. Bartlett, Mitchell J. Bartlett, Jean-Paul L. Wiegand, Allison J. Eby, Emily J. Monroe, Kathleen Gies, Luke Wohlford, Matthew J. Fell, Torsten Falk, Torsten Falk, Stephen L. Cowen, Stephen L. Cowen   +12 more
doaj   +1 more source

Exploring the Sensitivity of Prodromal Dementia with Lewy Bodies Research Criteria

Brain Sciences, 2022
Dementia with Lewy bodies (DLB) is an insidious neurodegenerative disease characterised by a precipitous decline in cognition, sleep disturbances, motor impairment and psychiatric features.
Joseph R. Phillips, Elie Matar, Kaylena A. Ehgoetz Martens, Ahmed A. Moustafa, Glenda M. Halliday, Simon J. G. Lewis   +5 more
doaj   +1 more source

Sex and age differences in the Multiple Sclerosis prodrome

Frontiers in Neurology, 2022
Background and objectivesLittle is known of the potential sex and age differences in the MS prodrome. We investigated sex and age differences in healthcare utilization during the MS prodrome.MethodsThis was a population-based matched cohort study linking
Fardowsa L. A. Yusuf, Fardowsa L. A. Yusuf, José M. A. Wijnands, Mohammad Ehsanul Karim, Mohammad Ehsanul Karim, Elaine Kingwell, Elaine Kingwell, Feng Zhu, Charity Evans, John D. Fisk, Yinshan Zhao, Ruth Ann Marrie, Helen Tremlett   +12 more
doaj   +1 more source

Trend of recognizing depression symptoms and antidepressants use in newly diagnosed Parkinson's disease: Population‐based study

Brain and Behavior, 2021
Objectives Although depression symptoms are common among patients with Parkinson's disease (PD), the medical literature still reports underrecognition of depression in patients with PD. Our main objective is to examine the trend of depression recognition
Khalid Orayj, Tahani Almeleebia, Easwaran Vigneshwaran, Sultan Alshahrani, Sirajudeen. S. Alavudeen, Wael Alghamdi   +5 more
doaj   +1 more source

Prodromal Cognitive Deficits and the Risk of Subsequent Parkinson’s Disease

Brain Sciences, 2022
Background: There is growing interest in identifying individuals who are in the prodromal phase of Parkinson’s disease (PD), as these individuals are potentially suitable for inclusion in intervention trials to prevent clinically manifest PD. However, it
Daniël H. B. Speelberg, Jules M. Janssen Daalen, Bastiaan R. Bloem, Jean-François Gagnon, Bart Post, Sirwan K. L. Darweesh   +5 more
doaj   +1 more source