Results 21 to 30 of about 47,670 (237)

Cognitive Profile in Ultra High Risk for Psychosis and Schizophrenia: A Comparison Using Coordinated Norms

Frontiers in Psychiatry, 2019
Background: Cognitive impairment is not only a core aspect of schizophrenia but also commonly observed in help-seeking youth at ultra high risk for psychosis (UHR), with potential implications for prognosis and individualized treatment. However, there is
Liss Anda, Liss Anda, Liss Anda, Kolbjørn K. Brønnick, Kolbjørn K. Brønnick, Jan Olav Johannessen, Jan Olav Johannessen, Inge Joa, Inge Joa, Rune A. Kroken, Rune A. Kroken, Rune A. Kroken, Erik Johnsen, Erik Johnsen, Erik Johnsen, Maria Rettenbacher, Farivar Fathian, Else-Marie Løberg, Else-Marie Løberg, Else-Marie Løberg, Else-Marie Løberg   +20 more
doaj   +1 more source

Metformin as a Potential Neuroprotective Agent in Prodromal Parkinson's Disease—Viewpoint

Frontiers in Neurology, 2020
To date, there are no clinically effective neuroprotective or disease-modifying treatments that can halt Parkinson's disease (PD) progression. The current clinical approach focuses on symptomatic management.
Carolina Sportelli, Daniele Urso, Daniele Urso, Peter Jenner, K. Ray Chaudhuri, K. Ray Chaudhuri   +5 more
doaj   +1 more source

Prolonged Wahnstimmung (delusional mood) without development of a psychotic illness in a 50-year-old male

Indian Journal of Psychiatry, 2017
Delusional mood, or Wahnstimmung, is a prodromal feature of an impending psychotic illness. In this case, the patient reports experiencing this sensation persistently since early childhood.
Benjamin A Stone, Peter Lepping
doaj   +1 more source

The Challenge and Opportunity to Diagnose Parkinson's Disease in Midlife

Frontiers in Neurology, 2019
Parkinson's disease (PD) is the most common neurodegenerative movement disorder that affects extensive regions of the nervous system. Its current clinical diagnosis is based on motor symptoms that appear late during disease progression when substantial ...
Alexander Kilzheimer, Thomas Hentrich, Simone Burkhardt, Julia M. Schulze-Hentrich   +3 more
doaj   +1 more source

Challenges and developments in research of the early stages of bipolar disorder

Brazilian Journal of Psychiatry
Recently, attention in the field of bipolar disorder (BD) has focused on prevention, including early detection and intervention, as these strategies have the potential to delay, lessen the severity, or even prevent full-blown episodes of BD.
Elisa Brietzke, Adriane R. Rosa, Mariana Pedrini, Mariane N. Noto, Flavio Kapczinski, Jan Scott   +5 more
doaj   +1 more source

A cross-sectional study of Parkinson’s disease and the prodromal phase in community-dwelling older adults in eastern Japan

Clinical Parkinsonism & Related Disorders, 2022
Introduction: Parkinson’s disease (PD) is more prevalent in the aging population, and epidemiological evidence must be constantly updated to provide an accurate understanding of PD prevalence.
Keita Taguchi, Kazuhiro Iwaoka, Takashi Yamaguchi, Ryota Nozaki, Yuriko Sato, Takahiro Terauchi, Yoshio Suzuki, Kai Takahashi, Kenta Takahashi, Hiroshi Akasaka, Naoki Ishizuka, Tetsuya Maeda   +11 more
doaj   +1 more source

The multiple sclerosis prodrome

Nature Reviews Neurology, 2021
A prodrome is an early set of signs, symptoms or other findings that occur before the onset of typical symptoms of a disease. Prodromal phases are well recognized in several neurological and inflammatory diseases, but the possibility of a prodrome in multiple sclerosis (MS) has received relatively little attention until the past few years.
Naila Makhani, Helen Tremlett
openaire   +3 more sources

Cutaneous Phosphorylated Alpha‐Synuclein in Lewy Body Dementia

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To determine the test performance of cutaneous phosphorylated alpha‐synuclein (P‐SYN) in dementia with Lewy bodies (DLB), individuals with reduced Montreal Cognitive Assessment (MoCA) and healthy controls. Methods This is the first subgroup analysis of the Synuclein‐One study, a prospective, blinded study evaluating P‐SYN detection ...
Christopher H. Gibbons, Todd Levine, Charles H. Adler, Bailey Bellaire, Ningshan Wang, Pinky Agarwal, Georgina M. Aldridge, Alexandru Barboi, Daniel Claassen, Virgilio G. H. Evidente, Douglas Galasko, Alejandra Gonzalez‐Duarte, Ramon Gil, Mark Gudesblatt, Stuart H. Isaacson, Horacio Kaufmann, Pravin Khemani, Rajeev Kumar, Guillaume Lamotte, Andy J. Liu, Nikolaus R. McFarland, Mitchell G. Miglis, Adam Reynolds, Gregory A. Sahagian, Marie‐Helene Saint‐Hilaire, Julie B. Schwartzbard, Wolfgang Singer, Michael J. Soileau, Steven Vernino, Patricio Millar Vernetti, Oleg Yerstein, Roy Freeman   +31 more
wiley   +1 more source

FDG PET metabolic signatures distinguishing prodromal DLB and prodromal AD

NeuroImage: Clinical, 2021
Patients with dementia with Lewy bodies (DLB) are characterized by hypometabolism in the parieto-occipital cortex and the cingulate island sign (CIS) on 18F-fluorodeoxyglucose (FDG) PET. Whether this pattern of hypometabolism is present as early as the prodromal stage of DLB is unknown.
Kejal Kantarci, Bradley F. Boeve, Scott A. Przybelski, Timothy G. Lesnick, Qin Chen, Julie Fields, Christopher G. Schwarz, Matthew L. Senjem, Jeffrey L. Gunte, Clifford R. Jack, Paul Min, Manoj Jain, Toji Miyagawa, Rodolfo Savica, Jonathan Graff-Radford, Hugo Botha, David T. Jones, David S. Knopman, Neill Graff-Radford, Tanis J. Ferman, Ronald C. Petersen, Val J. Lowe   +21 more
openaire   +3 more sources

Value of MRI Outcomes for Preventive and Early‐Stage Trials in Spinocerebellar Ataxias 1 and 3

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To examine the value of MRI outcomes as endpoints for preventive and early‐stage trials of two polyglutamine spinocerebellar ataxias (SCAs). Methods A cohort of 100 participants (23 SCA1, 63 SCA3, median Scale for the Assessment and Rating of Ataxia (SARA) score = 5, 42% preataxic, and 14 gene‐negative controls) was scanned at 3T up ...
Thiago J. R. Rezende, Emilien Petit, Young Woo Park, Sophie Tezenas du Montcel, James M. Joers, Jonathan M. DuBois, H. Moore Arnold, Michal Povazan, Ipek Özdemir, Guita Banan, Romain Valabregue, Philipp Ehses, Jennifer Faber, Chiadi U. Onyike, Peter B. Barker, Jeremy D. Schmahmann, Eva‐Maria Ratai, Sub H. Subramony, Thomas H. Mareci, Khalaf O. Bushara, Henry Paulson, Thomas Klockgether, Alexandra Durr, Tetsuo Ashizawa, Christophe Lenglet, Gülin Öz, READISCA Investigators   +26 more
wiley   +1 more source