Results 31 to 40 of about 47,670 (237)

A Prospective Study of Individuals at Risk of Multiple Sclerosis Informs the Design of Primary Prevention Studies

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective In multiple sclerosis, the optimal time for deploying a therapeutic intervention is before the central nervous system is damaged; given the success of trials treating the earliest stage of MS, the radiologically isolated syndrome, developing primary prevention strategies is an important next challenge.
Amy W. Laitinen, Ceren Tozlu, Tina Roostaei, Fatoumata Diallo, Kaho Onomichi, Jiyeon Son, Zongqi Xia, Philip L. De Jager   +7 more
wiley   +1 more source

A Narrative Review on Biochemical Markers and Emerging Treatments in Prodromal Synucleinopathies

Clinics and Practice
Alpha-synuclein has been associated with neurodegeneration, especially in Parkinson’s disease (PD). This study aimed to review clinical, biochemical, and neuroimaging markers and management of prodromal synucleinopathies.
Jamir Pitton Rissardo, Ana Leticia Fornari Caprara   +1 more
doaj   +1 more source

Relationship Between Neurologic Symptoms and Signs and FMR1 Genotype in Premutation Carriers

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background and Objectives Fragile X‐associated Tremor/Ataxia Syndrome (FXTAS) is the most severe late‐onset condition caused by a premutation in the FMR1 gene, characterized by expanded CGG triplet repeats of 55–200. Clinical presentations of FXTAS, including gait ataxia, kinetic tremor, cognitive decline, and rare Parkinsonism, are linked to ...
Flora Tassone, Freddy Chafota, Miguel E. Rentería, Randi J. Hagerman, Ellery Santos, Anna Atkinson, Nicholas G. Martin, Elsdon Storey, Danuta Z. Loesch   +8 more
wiley   +1 more source

A Systematic Comparison of Alpha‐Synuclein Seed Amplification Assays for Increasing Reproducibility

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Seed amplification assays (SAAs) enable ultrasensitive detection of misfolded α‐synuclein across biofluids and tissues. Yet, heterogeneity in protocols limits cross‐study comparability and clinical translation. Here, we review α‐synuclein SAA methods and their performance across various biological matrices.
Manuela Amaral‐do‐Nascimento, Daniela F. Santos, Tuane C. R. G. Vieira, Tiago F. Outeiro   +3 more
wiley   +1 more source

The Multiple Sclerosis Prodrome: Evidence to Action

Frontiers in Neurology, 2022
A growing body of work points toward the existence of a clinically symptomatic prodromal phase in multiple sclerosis (MS) that might span 5–10 years or more.
Helen Tremlett, Kassandra L. Munger, Naila Makhani   +2 more
doaj   +1 more source

PEDOT‐Based Eutectogel Electrode Arrays for Enhanced High‐Resolution Electrogastrography: Fabrication, Stability, and Wearable Performance

Advanced Functional Materials, EarlyView.
Here, we present a high‐density PEDOT eutectogel electrode array for enhanced body surface gastric mapping. Silver electrodes are blade‐coated onto flexible substrates, followed by electrogelation of PEDOT:PSS and the deposition of a PEDOT:LS eutectogel.
Christopher Slaughter, Luke Gatecliff, Xudong Tao, Ruben Ruiz‐Mateos Serrano, Amy T. Jin, Matias L. Picchio, Daniele Mantione, Antonio Dominguez‐Alfaro, George G. Malliaras   +8 more
wiley   +1 more source

Impairments in knowledge of social norms in presymptomatic, prodromal, and symptomatic frontotemporal dementia

Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring
INTRODUCTION We aimed to assess the knowledge of social norms in patients with behavioral variant frontotemporal dementia (bvFTD) with the Dutch version of the Social Norms Questionnaire (SNQ‐NL).
Liset deBoer, Esther van denBerg, Jackie M. Poos, Willeke Klop, Lucia A. A. Giannini, Julie F. H. De Houwer, Harro Seelaar, Lize C. Jiskoot   +7 more
doaj   +1 more source

Separable, symptom specific alterations in brain microstructure associated with early-stage Parkinson’s disease

Frontiers in Neuroscience
IntroductionParkinson’s Disease (PD) is diagnosed based on motor symptoms (bradykinesia, resting tremor, rigidity); yet non-motor symptoms such as sleep abnormalities, autonomic dysfunction, and cognitive changes often precede motor signs, fulfilling the
Mikhail Moshchin, Mikhail Moshchin, Maureen B. Haebig, Cuong P. Luu, Cuong P. Luu, Douglas C. Dean, Douglas C. Dean, Douglas C. Dean, Alan B. McMillan, Alan B. McMillan, Andrew L. Alexander, Andrew L. Alexander, Andrew L. Alexander, Samuel A. Hurley, Samuel A. Hurley, Catherine L. Gallagher, Catherine L. Gallagher, Aaron J. Suminski, Aaron J. Suminski   +18 more
doaj   +1 more source

Prodromal dementia with Lewy bodies: a case series of the 3 prodromal types from clinical practice

Case Reports in Neurology, 2023
Prodromal dementia with Lewy bodies (DLB) refers to a state prior to the onset of dementia with clinical signs or symptoms that may indicate the future development of DLB.
Tracy Tholanikunnel, Benjamin Chapin, Melissa Armstrong   +2 more
doaj   +1 more source

Autoimmune Encephalitis in Acute Care—Pathology, Diagnosis, and Management

Advanced Science, EarlyView.
ABSTRACT Autoimmune encephalitis (AE) is characterized by immune‐mediated inflammation of the brain parenchyma, presenting with various neurological syndromes, including but not limited to seizures, altered consciousness, neuropsychiatric symptoms, and movement disorders.
Suneesh Thilak, David Okoh, William Scotton, Shanika Samarasekera, Vikram Patil, Suresh Renukappa, Andrew Macduff, Subashini Suresh, Rajeev Krishnadas, Tonny Veenith   +9 more
wiley   +1 more source