Results 51 to 60 of about 47,670 (237)

Heterogeneity of prodromal Parkinson symptoms in siblings of Parkinson disease patients

npj Parkinson's Disease, 2021
A prodromal phase of Parkinson’s disease (PD) may precede motor manifestations by decades. PD patients’ siblings are at higher risk for PD, but the prevalence and distribution of prodromal symptoms are unknown.
Luca Baldelli, Sebastian Schade, Silvia Jesús, Sebastian R. Schreglmann, Luisa Sambati, Pilar Gómez-Garre, Claire Halsband, Giovanna Calandra-Buonaura, Astrid Daniela Adarmes-Gómez, Friederike Sixel-Döring, Corrado Zenesini, Chiara Pirazzini, Paolo Garagnani, Maria Giulia Bacalini, Kailash P. Bhatia, Pietro Cortelli, Brit Mollenhauer, Claudio Franceschi, PROPAG-AGEING consortium, Pablo Mir, Claudia Trenkwalder, Federica Provini   +21 more
doaj   +1 more source

Cognitive changes preceding Parkinson's disease: a systematic review and meta-analysis of prospective population-based studies

Frontiers in Aging Neuroscience
IntroductionVarious non-motor symptoms have been studied as part of the prodromal phase of Parkinson's disease (PD). However, studies assessing cognitive changes are scarce.MethodsWe systematically searched PubMed and SCOPUS to identify prospective ...
Noelia Peña Arauzo, Christoph Theyer, Florian Krismer, Atbin Djamshidian, Werner Poewe, Corinne Horlings, Beatrice Heim, Laura Zamarian, Philipp Mahlknecht   +8 more
doaj   +1 more source

The 3‐Hit Metabolic Signaling Model for Autism Spectrum Disorder: A Summary

Autism Research, EarlyView.
ABSTRACT Autism spectrum disorder (ASD) is a highly heritable yet environmentally sensitive neurodevelopmental condition whose biological heterogeneity has resisted a unifying causal explanation for over 100 years. The 3‐hit metabolic signaling model proposes that ASD arises from abnormal persistence of an evolutionarily conserved stress‐response ...
Robert K. Naviaux
wiley   +1 more source

Digital diagnostics, biomarkers and therapeutics in an evolving healthcare system: From promise to practice

British Journal of Clinical Pharmacology, EarlyView.
Abstract Health care is shifting towards a digital‐guided system, integrating digital diagnostics, biomarkers and therapeutics in many care pathways. However, despite rapid technological advancement and preliminary adoption accelerated by the COVID‐19 pandemic, a significant implementation gap persists. This narrative review explores the causes of this
Mees H. P. Stoop, Gertjan J. A. Driessen, Adam F. Cohen, Matthijs D. Kruizinga   +3 more
wiley   +1 more source

Dapagliflozin alleviates high‐fat‐induced obesity cardiomyopathy by inhibiting ferroptosis

ESC Heart Failure, Volume 12, Issue 2, Page 1358-1373, April 2025.
Abstract Aim: Dapagliflozin (Dapa) is a novel hypoglycaemic agent with multiple cardiovascular protective effects, and it is widely used in treatment of heart failure patients, but whether it can improve obese phenotype of heart failure and its mechanism is still unclear.
Di Chen, Jiahao Shi, Yue Wu, Lizhu Miao, Zilin Wang, Yixuan Wang, Siwei Xu, Yu Lou   +7 more
wiley   +1 more source

Patterns of Co-occurring Gray Matter Concentration Loss Across the Huntington Disease Prodrome

Frontiers in Neurology, 2016
Huntington disease is caused by an abnormally expanded CAG trinucleotide repeat in the HTT gene. Age and CAG-expansion number are related to age at diagnosis, and can be used to index disease progression.
Jennifer Ashley Ciarochi, Vince D Calhoun, Vince D Calhoun, Spencer Lourens, Jeffrey D Long, Jeffrey D Long, Hans J Johnson, Hans J Johnson, Jeremy Bockholt, Jingyu Liu, Sergey M Plis, Jane Paulsen, Jane Paulsen, Jessica A Turner, Jessica A Turner   +14 more
doaj   +1 more source

Inroads into epilepsy through high‐frequency oscillations: Achievements and benchmark areas for improvement

Epilepsia, EarlyView.
Abstract High‐frequency oscillations (HFOs) were discovered more than 20 years ago, and since then they have been studied intensively in the context of epilepsy. HFOs encompass a broad spectrum of oscillations, typically ranging from 80 Hz to several kHz, that include both normal and pathological oscillations, documented in people with epilepsy and ...
Christos Panagiotis Lisgaras, Birgit Frauscher, Jean Gotman, Julia Jacobs, Philippe Kahane, Richard J. Staba, Maeike Zijlmans   +6 more
wiley   +1 more source

Deep learning of wrist accelerometry from UK Biobank data identifies early movement signatures of knee osteoarthritis up to 5 years before diagnosis. [PDF]

Knee Surg Sports Traumatol Arthrosc
Abstract Purpose This study aims to test whether week‐long wrist accelerometry combined with deep learning can (i) distinguish healthy individuals from people with knee osteoarthritis (KOA), (ii) separate prodromal KOA from established KOA, and (iii) identify individuals who will receive a KOA diagnosis within 5 years.
Smits Serena R, Hirschmann MT, Matziolis G, von Eisenhart-Rothe R, Rueckert D, Hinterwimmer F, Valle C.   +6 more
europepmc   +2 more sources

Alexithymia in Schizophrenia and Psychosis Vulnerability: A Systematic Review and Meta‐Analysis

Journal of Clinical Psychology, Volume 81, Issue 6, Page 410-424, June 2025.
ABSTRACT Aims Disturbances involving impairments in experience and expression of affect are frequently identified in schizophrenia samples. Alexithymia underlies cognitive impairments in identification and expression of affect, further implicated in affect dysregulation.
Ercan Ozdemir, Zhuoni Xiao, Helen Griffiths, Angus MacBeth   +3 more
wiley   +1 more source

The Role of Magnetic Resonance Spectroscopy (MRS), Diffusion‐Tensor‐Imaging (DTI) and Structural MRI in the Alzheimer's Disease and Mild Cognitive Impairment Diagnosis: A Review

Journal of Magnetic Resonance Imaging, EarlyView.
ABSTRACT Alzheimer's disease (AD) is one of the most common neurological disorders affecting older adults, with approximately 7.2 million cases only in the United States. This number is projected to increase to 13.8 million in the United States by 2060, leading to increased expenditures for healthcare, long‐term care and hospice services. Consequently,
Valentina Zecca, Gianmauro Palombelli, Nicola Vanacore, Rossella Canese   +3 more
wiley   +1 more source