Results 71 to 80 of about 116,515 (261)

The role of histone modifications in transcription regulation upon DNA damage

FEBS Letters, EarlyView.
This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley   +1 more source

Modern trends and challenges of development of global aluminum industry

Metalurgija, 2017
This article overviews complex study into modern trends and challenges of development of global aluminum industry. Dynamics, structure, and segmentation of global aluminum market are discussed in terms of systematic analysis.
M. N. Dudin, N. A. Voykova, E. E. Frolova, J. A. Artemieva, E. P. Rusakova, A. H. Abashidze   +5 more
doaj  

Substrate specificity of Burkholderia pseudomallei multidrug transporters is influenced by the hydrophilic patch in the substrate‐binding pocket

FEBS Letters, EarlyView.
Multidrug transporters BpeB and BpeF from the Gram‐negative pathogen Burkholderia pseudomallei have a hydrophilic patch in their substrate‐binding pocket. Drug susceptibility tests and growth curve analyses using an Escherichia coli recombinant expression system revealed that the hydrophilic patches of BpeB and BpeF are involved in the substrate ...
Ui Okada, Satoshi Murakami
wiley   +1 more source

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

Mechanisms of parasite‐mediated disruption of brain vessels

FEBS Letters, EarlyView.
Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira, Sílvia Arroz‐Madeira, Cláudio A. Franco, Sara Silva Pereira   +3 more
wiley   +1 more source

Time after time – circadian clocks through the lens of oscillator theory

FEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo, Carolin Ector, Hanspeter Herzel   +2 more
wiley   +1 more source

Rethinking the Geometry of the Demand and Supply Functions [PDF]

Romanian Economic Journal, 2019
This paper attempts to revisit the geometry of the demand and supply functions in economic analysis, taking mathematical exigencies into account. Leaning on the fundamental principles that guide the theory of demand and supply, the paper uses the ...
Saidou Baba Oumar
doaj  

Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions

FEBS Letters, EarlyView.
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf, Nicholas F. Downing, Kaitlyn M. Mills, Samuel C. Metcalfe, Alexander E. Kritzer, Lindsey D. Mayo, Peter C. Hollenhorst   +6 more
wiley   +1 more source

Sonora State Producer and Strategic Exporter of Copper

Expert Journal of Economics, 2017
This paper presents a study on the importance of copper production in the State of Sonora, Mexico. Important data will be presented with total relevance to the current economic framework in which it will be possible to determine through a thorough ...
Rosalina JAIME MEULY, Daniela GORMITH
doaj  

Les mini-séries françaises : réflexions sur l'écriture d'un format hybride

Cahiers de Narratologie
This article explores the writing of French mini-series through the creative, economic and industrial challenges they pose. Drawing on testimonies from industry professionals and recent data, it highlights the specific features of this hybrid format ...
Charlotte Servel
doaj   +1 more source