Results 91 to 100 of about 143,442 (313)
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Distributional Impacts of Country-of-Origin Labeling in the U.S. Meat Industry [PDF]
Concerns about the negative effects of U.S. meat and livestock imports on domestic livestock prices have increased interest in country-of origin labeling (COOL) legislation.
Atwood, Joseph A. +2 more
core +1 more source
“They Collected What Was Left of the Scraps”: Food Surplus as an Opportunity and Its Legal Incentives [PDF]
, 2013 For many years the problem of food security has been addressed only in relation to developing countries, due to the fact that people in developed nations had a relatively abundant supply of food.
Planchenstainer, Francesco
core +1 more source
Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source
Direct pathway of nitrate produced from surplus nitrogen inputs to the hydrosphere [PDF]
Proceedings of the National Academy of Sciences, 2014 In PNAS, Sebilo et al. (1) present the fate of labeled nitrate in the soil–plant system over three decades and attempt to determine “to which extent and over which time periods fertilizer N stored in soil organic matter is rereleased for either uptake in crops or export into the hydrosphere.” I suspect that this mechanism of immobilization ...
openaire +2 more sources
Effect Of Import Tariff Implementation Policy On Refined Sugar Product Competitiveness In Indonesia [PDF]
This research is intent to determining: (a) the effect of welfare distribution with applied import tariff of the government revenue, consumer expenditures, producer revenues, and efficiency losses (in production, in consumption and net effect), and (b ...
Rustam, Rizal
core +1 more source
The macroeconomic cost of catastrophic pollinator declines [PDF]
, 2016 We develop a computable general equilibrium (CGE) approach to assess the macroeconomic impacts of productivity shocks due to catastrophic losses of pollination ecosystem services at global and regional scales.
Bauer, Dana Marie, Sue Wing, Ian
core +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Estimation of Economic Returns to Soil and Water Conservation Research – An Ex Ante Analysis [PDF]
The economic returns to investment made in soil and water conservation research have been analyzed. Technologies such as conservation furrow, residue incorporation have been found to be economically viable under farmers’ conditions. The study has covered
Kareemulla, Kalakada +4 more
core +1 more source
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source