Results 121 to 130 of about 143,687 (314)
FEBS Open Bio, EarlyView.Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane +11 more
wiley +1 more source
EFFECTS OF MORE OPEN TRADE ON CATTLE PRODUCTION, BEEF CONSUMPTION, AND WELFARE IN THE CENTRAL CORRIDOR OF WEST AFRICA [PDF]
The magnitude and direction of trade flows in cattle and beef, and how cattle production and beef consumption adjust in response to more open trade in the Central Corridor (an acronym for the sub-region that includes Ghana, Cote d'Ivoire, Mali, and ...
Asuming-Brempong, Samuel +1 more
core +1 more source
Cutaneous Melanoma Drives Metabolic Changes in the Aged Bone Marrow Immune Microenvironment
Aging and Cancer, EarlyView.Melanoma, the deadliest form of skin cancer, increasingly affects older adults. Our study reveals that melanoma induces changes in iron and lipid levels in the bone marrow, impacting immune cell populations and increasing susceptibility to ferroptosis.
Alexis E. Carey +12 more
wiley +1 more source
Aging and Cancer, EarlyView.Natural products target the aging kidney in diabetic nephropathy by restoring the AMPK–SIRT1–Nrf2 axis, reducing oxidative stress, inflammation, fibrosis, and cellular senescence while enhancing mitochondrial biogenesis and antioxidant defenses.
Sherif Hamidu +8 more
wiley +1 more source
FUTILITY OF TARGETED FISH TARIFFS AND AN ALTERNATIVE [PDF]
Targeted tariffs are a common tool used by importing countries to protect domestic fish producers. Unfortunately, such tariffs, in general, are ineffectual. The reason is twofold.
Kinnucan, Henry W.
core +1 more source
Inhibition of Classical and Alternative Complement Pathway by Ravulizumab and Eculizumab
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective To explore the feasibility of classical (CH50) and alternative (AH50) complement pathway activity as potential biomarkers for treatment guidance and monitoring during therapy with ravulizumab in patients with generalized myasthenia gravis (gMG) and compare these to therapeutic drug monitoring under eculizumab.
Lea Gerischer +14 more
wiley +1 more source
Welfare Implications of Washington Wheat Breeding Programs [PDF]
We calculate the welfare effects of the WSU wheat breeding programs for producers and consumers in Washington State, Oregon, Idaho, the United States and the rest of the world.
Marsh, Thomas L., Nogueira, Lia
core +1 more source
Post‐COVID Fatigue Is Associated With Reduced Cortical Thickness After Hospitalization
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Neuropsychiatric symptoms are among the most prevalent sequelae of COVID‐19, particularly among hospitalized patients. Recent research has identified volumetric brain changes associated with COVID‐19. However, it currently remains poorly understood how brain changes relate to post‐COVID fatigue and cognitive deficits.
Tim J. Hartung +190 more
wiley +1 more source
Downstream Concentration and Producer's Capacity Choice [PDF]
This paper studies how buyers' integration affects the capacity choice of a producer. Contrary to "conventional wisdom", we show that, under natural assumptions, integration may lead to a higher equilibrium supply level.
João VIEIRA-MONTEZ
core
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Super‐Refractory Status Epilepticus (SRSE) is a rare, life‐threatening neurological emergency with unclear etiology in many cases. Mitochondrial dysfunction, often due to disease‐causing genetic variants, is increasingly recognized as a cause, with each gene producing distinct pathophysiological mechanisms.
Pouria Mohammadi +2 more
wiley +1 more source