Results 71 to 80 of about 143,442 (313)

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

open access: yesMolecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir   +12 more
wiley   +1 more source

Optimal Institutional Mechanisms for Funding Generic Advertising: An Experimental Analysis [PDF]

open access: yes
Given the uncertain legal status of generic advertising programs for agricultural commodities, alternative voluntary funding institutions are investigated hat could provide a high level of benefits to producers.
Kaiser, Harry M.   +2 more
core   +1 more source

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

open access: yesMolecular Oncology, EarlyView.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz   +15 more
wiley   +1 more source

Plusvalía semántica: bosquejo de una teoría pragmática de la recepción de los medios

open access: yesEstudios sobre las Culturas Contemporáneas, 1990
Taking from critical theory the concepts of economic and repressive surplus, the term meaning surplus is presented in order to characterise reception of massive communication.
Klaus Bruhn Jensen
doaj  

Oilseeds sector in India: A trade policy perspective

open access: yesThe Indian Journal of Agricultural Sciences, 2019
The government had been intervening in the oilseed sector from time to time in the form of production, price and trade related policies to improve edible oils availability in India. In this paper, we analyse the impact of trade policy measures adopted by
RENJINI V R, GIRISH K JHA
doaj   +1 more source

WELFARE EFFECTS OF ECO-LABEL PROLIFERATION: TOO MUCH OF A GOOD THING? [PDF]

open access: yes
Given that existing food eco-labels are still not well defined in consumers' experience, there is potential for new labels to generate more confusion. Consumers incur fixed costs to learn about a label's meaning. Market shares for existing certifications
Lohr, Luanne
core   +1 more source

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

open access: yesMolecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed   +10 more
wiley   +1 more source

Investigating Welfare Effect of Climate Change on the Wheat Products in Iran

open access: yesمجله اقتصاد و توسعه کشاورزی, 2015
Agricultural sector will be most affected by climate change due to its extensive interaction with the environment. and as a result of changing production conditions, community welfare is changed.
S. Khalilian   +3 more
doaj  

ESTIMATING PRODUCER'S SURPLUS WITH THE CENSORED REGRESSION MODEL: AN APPLICATION TO PRODUCERS AFFECTED BY COLUMBIA RIVER BASIN SALMON RECOVERY [PDF]

open access: yes
Application of the tobit model to estimate economic welfare is transferred from the consumer side to the producer side. Supply functions are estimated for multioutput irrigators in the Pacific Northwest.
Gollehon, Noel R.   +2 more
core   +1 more source

Molecular characterisation of human penile carcinoma and generation of paired epithelial primary cell lines

open access: yesMolecular Oncology, EarlyView.
Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad   +12 more
wiley   +1 more source

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