Results 141 to 150 of about 1,694,885 (313)
Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source
Multi-observable Uncertainty Relations in Product Form of Variances. [PDF]
Sci Rep, 2016 Qin HH, Fei SM, Li-Jost X.
europepmc +1 more source
Information Flow Structure in Large-Scale Product Development Organizational Networks [PDF]
In recent years, understanding the structure and function of complex networks has become the foundation for explaining many different real- world complex social, information, biological and technological phenomena.
Yaneer Bar-Yam, Dan Braha
core
Gaussian dynamics equation in normal product form
, 2022 In this paper, we discuss the normal product form of the density operator of multimode Gaussian states, and obtain the correlation equation between the kernel matrix R of the Gaussian density operator in the normal product form and its kernel matrix G in
He, Rui
core
Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source
Applied SciencesIn the traditional decision-making process for product form design, designers and experts often prioritize schemes based on their own knowledge and experience.
Jian Chen +5 more
doaj +1 more source
Product-Form Stationary Distributions for Deficiency Zero Networks with Non-mass Action Kinetics. [PDF]
Bull Math Biol, 2016 Anderson DF, Cotter SL.
europepmc +1 more source
Molecular Oncology, EarlyView.Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang +12 more
wiley +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Molecular Oncology, EarlyView.Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute +4 more
wiley +1 more source