Results 141 to 150 of about 32,648 (253)

Beyond the label: Rethinking off‐label drug use in paediatrics. Towards a scientifically grounded and safer future for paediatric pharmacotherapy

British Journal of Clinical Pharmacology, EarlyView.
Abstract Despite regulatory progress being made in the past two decades, off‐label drug use in paediatrics remains pervasive, with prevalence estimated between 3% and 97% of prescriptions across different clinical settings. Off‐label use—defined as prescribing outside the conditions described in the Summary of Product Characteristics (SmPC)—is often ...
Tjitske M. van der Zanden, Miriam G. Mooij, Matthijs de Hoog, Saskia N. de Wildt   +3 more
wiley   +1 more source

The Impact of Digital Platform Rules on the Mental Health of Minors and the Response of Chinese Law: An Analysis Based on Therapeutic Jurisprudence. [PDF]

Psychol Res Behav Manag
Zhang J, Li J.
europepmc   +1 more source

Mobile health interventions to improve adherence to oral anticoagulant treatment: A systematic review and critical analysis

British Journal of Clinical Pharmacology, EarlyView.
Aims Non‐adherence to oral anticoagulants (OACs) is associated with significant morbidity and mortality. Mobile health (mHealth) interventions have been used to improve medication adherence across the three phases of initiation, implementation and persistence.
Non Davies, Elin Haf Davies, Dyfrig A. Hughes   +2 more
wiley   +1 more source

Legal and ethical reflections on the use of artificial intelligence in the diagnosis and treatment of cancer: who assumes responsibility? [PDF]

Front Artif Intell
Prunoiu VM, Juverdeanu O, Cosma C, Laurentiu S, Strâmbu V, Petru AR, Stana M, Brătucu MN.   +7 more
europepmc   +1 more source

Translational development of crisugabalin for neuropathic pain

British Journal of Clinical Pharmacology, EarlyView.
Abstract Crisugabalin (HSK16149) is a next‐generation α2δ ligand developed to preserve the mechanistic rationale of gabapentinoids while refining target engagement and exposure‐related tolerability constraints. We performed a translational review of molecular/structural studies, in vivo pharmacology and behavioural safety assessments, phase I clinical ...
Rafael Batista João, Jilly Octoria Tagore Chan, Luísa Mendes Araújo, André Batista João, Raquel Mattos Filgueiras, Paulo César Ragazzo   +5 more
wiley   +1 more source

Correction: Mixed-microbe solid-state fermentation modulates the physicochemical and aroma profiles of <i>Eucommia ulmoides</i> leaf. [PDF]

Front Microbiol
Gu B, Zhang W, Guo B, Wang X, Wu F, Zhang Y, Tian H, Li X, Huang J.   +8 more
europepmc   +1 more source

The impact of the current student loans regime on Muslim student engagement and retention in English higher education

British Educational Research Journal, EarlyView.
Abstract There is much interest in the potential for an alternative funding system for higher education students in England to support the spiritual and worldly needs of British Muslim students. At the heart of this issue lies a tension over whether the student financing system in English HE is haram, or forbidden under Islamic (Shari'ah) law, because ...
Richard Hall, Yusraa Maryam, Sumeya Loonat   +2 more
wiley   +1 more source

Liability in Telesurgery: Navigating Legal, Ethical, and Cross-Border Challenges in the Era of Global Surgical Care. [PDF]

Med Princ Pract
Al Sabah S, Al Haddad E.
europepmc   +1 more source

Beyond salaries: Teachers' experiences of navigating early years education amid economic instability in Türkiye

British Educational Research Journal, EarlyView.
Abstract The intersection of economic conditions and early years education has long been debated, particularly where financial constraints shape educational practice and professional realities. Türkiye, characterised by high inflation and structural vulnerabilities in purchasing power parity, provides a critical context for examining how economic ...
Ebru Aydın, Şerif Yüksel
wiley   +1 more source

Remdesivir from failed Ebola drug to first FDA-approved COVID-19 antiviral: The medico-legal integration. [PDF]

iScience
Tsai TH.
europepmc   +1 more source