Results 71 to 80 of about 1,806,355 (304)

Cell wall target fragment discovery using a low‐cost, minimal fragment library

open access: yesFEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan   +5 more
wiley   +1 more source

An information technology view of manufacturing automation - Product life-cycle management [PDF]

open access: yes, 2016
Different approaches of product life-cycle management will be demonstrated to show that unlike several engineering paradigms it is easy to understand, however difficult to implement and to follow.
Kovács, György, Petunin, A
core   +3 more sources

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

open access: yesFEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson   +7 more
wiley   +1 more source

The product life cycle of durable goods [PDF]

open access: yes
The model presented here derives the product life cycle of durable goods. It is based on the idea that the purchase process consists of first purchase and repurchase.
Kaldasch, Joachim
core   +1 more source

Structural biology of ferritin nanocages

open access: yesFEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Development of a methodological framework for calculation of carbon footprint of rice production in Vietnam

open access: yesVietnam Journal of Science, Technology and Engineering, 2017
Currently, there are various standards and guidelines to calculate product carbon footprints in the world such as the Greenhouse Gas (GHG) Protocol of the World Resources Institute/World Business Council for Sustainable Development (WRI/WBCSD), ISO ...
Minh Trang Dao, Thi Lan Huong Huynh
doaj   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Erratum to: Life Cycle Assessment of Heaven Mushroom Product [PDF]

open access: yesE3S Web of Conferences, 2021
Sukkanta Phatcharapron   +1 more
doaj   +1 more source

Product Life Cycle Planning [PDF]

open access: yes, 2003
Abstract : Regional Sediment Management (RSM) refers to the effective use of littoral, estuarine, and riverine sediment resources in an environ-mentally effective and economical manner. The U.S. Army Corps of Engineers manages lands and waterways across the United States.
William J. Wolfe   +6 more
openaire   +1 more source

A statistical distribution useful in product life-cycle modeling [PDF]

open access: yes
Starting from some recent results presented by Isaic â Maniu and Vodă (2008) regarding the Product Life â Cycle (PLC), we propose here an alternative statistical distribution in order to describe all four phases of a product life span.
Emil PETRESCU
core  

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