Results 81 to 90 of about 1,806,355 (304)

Integrated Application of the Target Co-sting and Life Cycle Costing in Contemporary Business Environment [PDF]

open access: yes, 2015
Contemporary business environment is characterized by frequent changes in business conditions. Technological innovations and changes in customers’ perception affect on the continuous improvement in quality, availability and functionality of the product ...
Hrvoje Perčević   +2 more
core   +2 more sources

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

open access: yesFEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai   +9 more
wiley   +1 more source

Product life cycle: the evolution of a paradigm and literature review from 1950-2009 [PDF]

open access: yes, 2015
Copyright © 2012 Taylor & Francis. This is an Accepted Manuscript of an article published by Taylor & Francis in Production Planning & Control: The Management of Operations on 17 June 2011 (online), available online: http://www.tandfonline.com/10.1080 ...
Cao, Hui, Folan, Paul
core   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

open access: yesFEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes   +4 more
wiley   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

open access: yesFEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto   +3 more
wiley   +1 more source

Thesis on Firm Life Cycle, Product Life Cycle, and Retail Life Cycle

open access: yesManagement (Split), 1997
In this paper, the conceptions on firm life cycle, product life cycle and retail life cycle (institution and shop) have been analyzed. Conceptions based on biology have been compared as well. In retail forms specific qualities of particular approaches are described, connected with the efforts of a firm on that development, using price and other ...
openaire   +1 more source

ON A MODEL REGARDING THE PRODUCT LIFE CYCLE [PDF]

open access: yes
In this paper we analyze a modified model for the so-called PLC – Product Life Cycle, the original model being proposed by N. Al. Pop (2000). This PLC is considered here from a reliability theory viewpoint: our modification lies in the fact that the PLC -
Alexandru ISAIC-MANIU, Viorel Gh. VODĂ
core  

Sustainable product development strategies: Business planning and performance implications [PDF]

open access: yes, 2012
Copyright © 2012 by Institution of Mechanical Engineers. This is the author's accepted manuscript. The final published article is available from the link below.Manufacturing firms are under many financial and competitive pressures which focus attention ...
Aurich JC   +6 more
core   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

open access: yesFEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa   +5 more
wiley   +1 more source

When Product Life Cycle Meets Customer Activity Cycle [PDF]

open access: yes, 2007
Manufacturing companies have traditionally focused their efforts on designing, developing and producing products to offer on the market. Today global competition and demands for greater company responsibility of products throughout their entire life ...
Tan, Adrian Ronald
core  

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