Synergistic Mn‐MOF Activation of Pistol Ribozymes for Cancer Immunotherapy
A Mn2+‐based metal–organic framework delivers a catalytic Pistol ribozyme for targeted PD‐L1 mRNA cleavage in tumor cells, with the released Mn2+ not only inducing immune activation in immune cells but also increasing the Pistol ribozyme catalytic activity.
Ming Zhao +10 more
wiley +1 more source
Correction: Exosomal lncRNA XR_001793654.1 in human cardiac explant-derived alleviates atrial fibrillation via abolishing the miR-107-3p-mediated KLF13 inhibition. [PDF]
Liang Y, Li D, Wang H, Tian Y.
europepmc +1 more source
MELEGROS: Monolithic Elephant‐Inspired Gripper with Optical Sensors
MELEGROS is a monolithic, elephant‐inspired soft gripper integrating 3D‐printed optical sensors within a pneumatically actuated lattice. Simulation‐guided design decouples tactile and proprioceptive sensing. Characterized through grasping tests, MELEGROS can reach, scoop, and grasp, showcasing a paradigm where fully embedded sensing and continuous ...
Petr Trunin +4 more
wiley +1 more source
The fallacy of meritocracy in the real-life social order. [PDF]
Teles da Silva L, Abramov DM.
europepmc +1 more source
Low‐frequency noise fingerprints in hafnia ferroelectrics provide a quantitative handle to resolve the long‐standing debate between polarization‐mediated and defect‐mediated switching. By tuning oxygen vacancy density via ALD O3 dose time and applying a physically constrained deconvolution, we extract bias‐resolved current fractions for both mechanisms
Ryun‐Han Koo +8 more
wiley +1 more source
A scalable automated framework for multiply-accumulate unit design in high-performance computing applications. [PDF]
Venkatachalam A +2 more
europepmc +1 more source
A new vertical transistor design with a dual‐modulation strategy is proposed to overcome the limitations of conventional transistors. This architecture uses a micro‐hole patterned electrode and a graphene electrode to enhance channel control and incorporates a leakage blocking layer to suppress off‐state current.
Goeun Pyo +6 more
wiley +1 more source
From lab to market: industrialization barriers and regulation optimization for new breeding technologies in China. [PDF]
Qin Y, Su K.
europepmc +1 more source
The HfxZr1‐xO2‐based ferroelectric/antiferroelectric bilayer capacitor exhibits morphotropic‐phase‐boundary behavior with a high dielectric constant (∼52) at 2 V. Phase engineering stabilizes o/t‐phase coexistence and suppresses m‐phase formation, enabling capacitance enhancement and self‐optimization under cycling for scalable low‐voltage, high‐κ ...
Junseok Kim +5 more
wiley +1 more source
Engineering the next generation of CAR T- cells: precision modifications, logic gates and universal strategies to overcome exhaustion and tumor resistance. [PDF]
Garcia-Robledo JE +11 more
europepmc +1 more source

