Results 41 to 50 of about 3,837,809 (259)

Investigating transcription factor dynamics in health and disease using FRAP

open access: yesFEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj   +3 more
wiley   +1 more source

Making mathematics meaningful: Using student-initiated problems to situate mathematics [PDF]

open access: yes, 2014
Mathematics is everywhere-from the minute we open our eyes to check the alarm clock and calculate how many minutes extra we can afford to lie in bed, to measuring out our cereal for breakfast and estimating if we have enough petrol to make the 18 ...
Brough, Chris Jane, Calder, Nigel Stuart
core  

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

open access: yesFEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri   +5 more
wiley   +1 more source

Students' perspectives on the nature of mathematics [PDF]

open access: yes, 2006
This paper reports on one small component of a much larger study that explored the perspectives of students towards mathematics learning. Students were asked “What do you think maths is all about?” Some students responded in terms of mathematical content.
Taylor, Merilyn   +3 more
core   +1 more source

Promoting active citizenship in mathematics teaching [PDF]

open access: yes, 2019
Mathematical and scientific knowledge are integral to preparing our population to be actively engaged and responsible citizens. Science and mathematics education, however, has mainly focused on concepts and skills detached from societal implications.
Doorman, L.M.   +6 more
core   +2 more sources

Developing Digital Pocketbook Interactive Based on HTML-5 to Improve Mathematics Learning Outcomes

open access: yesJournal of Integrated Elementary Education
Interactive learning media have an essential role in realizing interesting and interactive mathematics learning, so they have the potential to optimize student learning outcomes.
Delia Sonanta Nurvidia, Sigit Yulianto
doaj   +1 more source

Hubungan Antara Self-Confidence Mahasiswa dengan Kemampuan Pemahaman Matematis Dalam Perkuliahan Kapita Selekta Matematika IV

open access: yesJTAM (Jurnal Teori dan Aplikasi Matematika), 2018
Abstrak: Penelitian ini bertujuan untuk menelaah hubungan antara self-confidence mahasiswa dengan kemampuan pemahaman matematis. Penelitian dilaksanakan di Program Studi Pendidikan Matematika Universitas Galuh dengan sampel penelitian mahasiswa tingkat 2
Angra Meta Ruswana, Lala Nailah Zamnah
doaj   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

open access: yesFEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

Maori preservice primary teachers’ responses to mathematics investigations [PDF]

open access: yes, 2006
There has been concern for some years about the low mathematics achievement of Maori students in New Zealand. This case study reports on the responses of 18 Maori preservice teachers to investigative approaches to learning mathematics during their ...
Hāwera, Ngārewa
core   +1 more source

How Science-Mathematics based Fairytale Book Enhance Critical Thinking Skills and Curiosity in Elementary School Students?

open access: yesAl Ibtida: Jurnal Pendidikan Guru MI
This study aims to develop a fairytale book based on Science-Mathematics suitable to enhance critical thinking skills and curiosity and reveal the effectiveness of the fairytale book based on Science-Mathematics to improve critical thinking skills and ...
Nur Luthfi Rizqa Herianingtyas   +4 more
doaj   +1 more source

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