A dual‐functional hafnium oxide nanoplatform is developed for enhanced cancer radiotherapy. This innovative system combines the inherent radiosensitizing properties of high‐Z hafnium oxide with Bcl‐2 gene‐silencing capabilities. The nanoplatform demonstrated synergistic enhancement of radiotherapy efficacy through increased generation of reactive ...
Seungyong Shin+12 more
wiley +1 more source
Analysis of shared pathogenic mechanisms and drug targets in myocardial infarction and gastric cancer based on transcriptomics and machine learning. [PDF]
Ma J, Hou S, Gu X, Guo P, Zhu J.
europepmc +1 more source
The Empirical Distribution of a Large Number of Correlated Normal Variables
David Azriel, Armin Schwartzman
semanticscholar +1 more source
This proof‐of‐concept study involves high‐throughput teratogenicity screening of compounds using XEn/EpiCs, a 3D stem cell‐based embryo model, within microwells. The term ‘morphotoxicity’ is introduced to complement traditional cytotoxicity assays through automated feature extraction and machine‐learning‐assisted classification of morphologies.
Vinidhra Shankar+4 more
wiley +1 more source
Handling missing data in variational autoencoder based item response theory. [PDF]
Veldkamp K, Grasman R, Molenaar D.
europepmc +1 more source
Tail distribution of the maximum of correlated Gaussian random variables
Z. Botev, M. Mandjes, Ad Ridder
semanticscholar +1 more source
Tattoo Assisted Optical Sensor System for Multimodal Discrete Physiological Sensing
Conventional temporary tattoos can be used for improving the speckle imaging signal‐to‐noise ratio and stability of the specifically developed device for capturing skin motion related to physiological activities beneath the skin. This allows for sensing multimodal electrophysiological signals and physiological events from the skin consistent with ...
Zihuan Wu+5 more
wiley +1 more source
Prediction of KRAS gene mutations in colorectal cancer using a CT-based radiomic model. [PDF]
Wang W+8 more
europepmc +1 more source
Pyrophosphate‐Containing Calcium Phosphates Negatively Impact Heterotopic Bone Quality
The role of calcium pyrophosphate (Ca‐PP) in heterotopic bone formation and material degradation is investigated using calcium phosphate (CaP) compositions with varying Ca‐PP content. Results show that Ca‐PP does not impede heterotopic bone formation, minimally affects CaP degradation at non‐osseous sites, and increases phagocytosis.
Martina Jolic+7 more
wiley +1 more source
The tongue coating microbiome is perturbed in atrial fibrillation and partly normalized after catheter ablation. [PDF]
Wang L+21 more
europepmc +1 more source