Results 71 to 80 of about 13,794 (215)
Advanced Science, EarlyView.AI‑guided single‑cell transcriptomics identifies OGT as a key regulator enriched in rheumatoid arthritis fibroblast‑like synoviocytes (RA‐FLSs). Inflammatory stimuli activate the OGT–SAP130 axis, which modulates the H3K27ac/H3K27me3 balance and epigenetically silences BTG2, promoting aggressive transformation of RA‑FLSs.
Duoli Xie +14 more
wiley +1 more source
Machine learning application in batch scheduling for multi-product pipelines: A review
Journal of Pipeline Science and EngineeringBatch scheduling is a crucial part of pipeline enterprise operation management, especially in the context of market-oriented operation. It involves 3 main tasks: quickly preparing batch plans, accurately tracking interface movement, and operation ...
Renfu Tu +8 more
doaj +1 more source
Advanced Science, EarlyView.Integrative multi‐cohort analyses identify 14‐3‐3γ as a biomarker and regulator of cognitive vulnerability. Experimental studies show that 14‐3‐3γ loss is associated with Tau Thr205 phosphorylation, synaptic dysfunction, and cognitive impairment, while genetic overexpression or pharmacological stabilization of 14‐3‐3γ confers protective effects in ...
Shouqiang Zhu +5 more
wiley +1 more source
The Interplay of Curvature, Geometry, and Topology Shapes Tissue Organisation in Epithelial Shells
Advanced Science, EarlyView.Purely geometric 3D Voronoi models predict the organisation of epithelial shells. The interplay of curvature, geometry, and topology enriches the number of pentagons in shells with lower number of cells. Small MDCK cysts and Mouse embryos match the top polygonal configurations in a compactness‐based ranking derived from the Voronoi model. In conclusion,
Laura Morato +9 more
wiley +1 more source
Advanced Science, EarlyView.CDegSR, a new tool for imaging RNA at single molecule level in living cells was developed by researchers. Background noise was eliminated by protein engineering and making it degrade when not bound to its target. This allowed individual RNA molecules to be clearly imaged and tracked.
Shipeng Shao, Hongchen Zhang
wiley +1 more source
Advanced Science, EarlyView.Mesenchymal GSCs preferentially uptake palmitic acid, thereby promoting ZDHHC12‐mediated LDHA palmitoylation. This modification enhances LDHA enzymatic activity, drives glycolytic reprogramming, and facilitates exosomal LDHA‐mediated TAM regulation.
Zijie Gao +20 more
wiley +1 more source
You-qi chuyunObjectiveAgainst the backdrop of the “dual carbon” goals, methanol holds significant potential as a clean liquid fuel and hydrogen carrierfor large-scale pipeline transport.
Shujuan QIU +7 more
doaj +1 more source
TECTB Variants Reveal Tectorial Membrane Vulnerability in Dominant Non‐Syndromic Hearing Loss
Advanced Science, EarlyView.TECTB is a non‐collagenous protein of the tectorial membrane – an extracellular matrix of the cochlea. This study identifies dominant missense variants in TECTB linked to human hereditary deafness in two unrelated families. Genetically engineered mice homozygous for one of the variants are profoundly deaf, whereas heterozygous mice have normal hearing ...
Evan B. Hale +23 more
wiley +1 more source
Известия Томского политехнического университета: Инжиниринг георесурсов, 2018 The relevance. Changes in technological parameters of product pumping at oil and gas pipelines operation in comparison with the stationary operating condition leads to appearance of additional mechanical stresses in the wall of pipes and to decrease in ...
Zukhra Khasanovna Pavlova +3 more
doaj +2 more sources
You-qi chuyunObjective Batch pipelining of product oils inevitably leads to oil mixing at the junction of oils transmitted in sequential batches within the pipelines. This disruption affects the formulation of station dispatching plans and offtake schemes. Therefore,
Jian DU +7 more
doaj +1 more source