Results 171 to 180 of about 578,139 (333)

State market surveillance of non-food products in Ukraine: analysis of the decision of the Constitutional Court of Ukraine № 9-r(ii)/2023 dated November 1, 2023 in case № 3-53/2022(126/22)

M. E. Dyrdin, T. P. Yatsyk
openalex   +2 more sources

Aberrant SUMOylation Restricts the Targetable Cancer Immunopeptidome

Advanced Science, EarlyView.
Pharmacological SUMOylation inhibition (SUMOi) counteracts tumor immune evasion by unmasking an immunogenic HLA‐I peptide and neoepitope repertoire. By restoring HLA‐I ligand availability through increased antigen processing and presentation, enhanced proteasomal cleavage, and modulated TAP1 peptide affinity, SUMOi boosts tumor immunogenicity ...
Uta M. Demel, Anna Meurer, Badeel Kh. Q. Zaghla, Bilge Atay, Daniel Steiert, Luca V. Hummel, Konstandina Isaakidis, Chuanbing Zang, Michael Korenkov, Marlon Schielin, Schayan Yousefian, Shima Mecklenbräuker, Marieluise Kirchner, Simon Haas, Antonia Busse, Philipp Mertins, Stefan Müller, Matthias Wirth, Martin G. Klatt, Ulrich Keller   +19 more
wiley   +1 more source

ETV1 Drives CD4+ T Cell‐Mediated Intestinal Inflammation in Inflammatory Bowel Disease Through Amino Acid Transporter Slc7a5

Advanced Science, EarlyView.
This study identifies the transcription factor ETV1 as a key driver of CD4⁺ T cell‐mediated intestinal inflammation in inflammatory bowel disease (IBD). ETV1 promotes CD4⁺ T cell activation, proliferation, and Th17 differentiation by activating the amino acid transporter SLC7A5, fueling metabolic reprogramming.
Yan Shi, Song Wang, Yuqing Yan, Wei Chen, Yingying Cao, Dafan Chen, Wei Chen, Caiyun Ma, Xinjian Wan   +8 more
wiley   +1 more source

Enhancing Postmarketing Surveillance of Medical Products With Large Language Models

Michael E. Matheny, Jie Yang, Joshua Smith, Colin G. Walsh, Mohammed Ali Al-Garadi, Sharon E. Davis, Keith Marsolo, Daniel Fabbri, Ruth Reeves, Kevin B. Johnson, Gerald J. Dal Pan, Robert Ball, Rishi Desai   +12 more
openalex   +1 more source

Syndromic Surveillance for E-Cigarette, or Vaping, Product Use–Associated Lung Injury [PDF]

, 2019
Kathleen P. Hartnett, Aaron Kite-Powell, Megan T. Patel, Brittani L. Haag, Michael Sheppard, Taylor Dias, Brian A. King, Paul Melstrom, Matthew D. Ritchey, Zachary Stein, Nimi Idaikkadar, Alana M. Vivolo‐Kantor, Dale A. Rose, Peter A. Briss, Jennifer E. Layden, Loren Rodgers, Jennifer Adjemian   +16 more
openalex   +1 more source

rWTC‐MBTA Vaccine, Alone and Enhanced with Anti‐PD1, Elicits Immune Responses against CNS and Peripheral B‐Cell Lymphoma

Advanced Science, EarlyView.
An autologous whole‐tumor‐cell vaccine (rWTC‐MBTA) is evaluated in murine CNS lymphoma. Subcutaneous vaccination activates dendritic cells, broadens T‐cell priming, and drives lymphocyte trafficking to brain tumors, producing durable tumor control. Longitudinal bioluminescence and adoptive‐transfer assays verify CNS engagement. Combination with anti‐PD‐
Yaping Zhang, Juan Ye, Mitchell Sun, Samik Chakraborty, Alex Valenzuela, Shuran Chen, Qingfeng Xue, Wenyu Shi, Karel Pacak, Herui Wang, Zhengping Zhuang   +10 more
wiley   +1 more source

Gender in Health product postmarketing surveillance Studies: A Scoping Review on the Conceptual and Methodological Approach

Mezza, Maurizia, Bohorquez, Jairo Duvan Vivas, Neva-Cruz, Angie Catalina   +2 more
openalex   +1 more source

Data from Surveillance Methods for Identifying, Characterizing, and Monitoring Tobacco Products: Potential Reduced Exposure Products as an Example

, 2023
Richard J. O’Connor, K. Michael Cummings, Vaughan W. Rees, Gregory N. Connolly, Kaila J. Norton, David Sweanor, Mark Parascandola, Dorothy K. Hatsukami, Peter G. Shields   +8 more
openalex   +1 more source

Precision Editing of NLRS Improves Effector Recognition for Enhanced Disease Resistance

Advanced Science, EarlyView.
Precision engineering of plant NLR immune receptors enables rational design of enhanced pathogen resistance through mismatched pairing, domain swapping, and targeted mutagenesis. These approaches achieve multi‐fold expansion in recognition breadth while minimizing autoimmunity risks and fitness penalties.
Vinit Kumar, Vishwa I. P. W. A. Kumara, Pradeepa C. G. Bandaranayake, Dong Yawen, Yang‐Yang Gao, Junfeng Liu, Ge‐Fei Hao, Xiu‐Fang Xin   +7 more
wiley   +1 more source

The Structure of Network Administration on the Example of the Organization Market Surveillance Regarding Product Safety in the European Union

, 2023
Agnieszka Żywicka, Katarzyna Kokocińska   +1 more
openalex   +2 more sources