Results 171 to 180 of about 581,657 (258)

Leveraging Artificial Intelligence and Large Language Models for Cancer Immunotherapy

Advanced Science, EarlyView.
Cancer immunotherapy faces challenges in predicting treatment responses and understanding resistance mechanisms. Artificial intelligence (AI) and machine learning (ML) offer powerful solutions for cancer immunotherapy in patient stratification, biomarker discovery, treatment strategy optimization, and foundation model development.
Xinchao Wu, Mengtao Sun, Lusheng Li, Jieqiong Wang, Shibiao Wan   +4 more
wiley   +1 more source

Country-level perspectives and priorities to guide the development of Invasive non-Typhoidal Salmonella (iNTS) vaccines: Insights from seven countries. [PDF]

PLoS Negl Trop Dis
Spasenoska D, Kahn AL, Wilder-Smith A, Bentsi-Enchill AD, Hwang YH, Gunarathna S, Kim JH, Lee JS.   +7 more
europepmc   +1 more source

Dual Covalent Targeting of STING Cysteines 292/309 Disrupts Functional Oligomerization and Enables Potent Antagonist Development

Advanced Science, EarlyView.
We report a rational design strategy for STING antagonists by dual covalent targeting of Cys292/309 in its C‐terminal domain, directly preventing functional oligomerization. Through covalent warhead repurposing, we identified P005091 and revealed its unique dual‐cysteine mechanism.
Yuxuan Zhao, Ling Huang, Wenjing Qin, Bin Zhang, Yang Yang, Xue Chen, Xiaoquan Wang, Weilin Zhou, Feiyang Chen, Zhenyu Li, Liyuan Le, Yiqiu Zhang, Zhen Xiang, Lu Zhang, Fei Wang, Dan Lei, Zi‐zhe Cai, Ying Gao, Yong Chen, Xuecen Wang, Junmin Quan, Shuixing Zhang, Xianzhang Bu, Xin Yue   +23 more
wiley   +1 more source

Detachment‐Induced FAK‐STAT3‐NNMT Inhibits CTCs Anoikis to Promote Breast Cancer Metastasis by Enhancing Fatty Acid Oxidation

Advanced Science, EarlyView.
The FAK‐STAT3‐NNMT axis drives anoikis resistance in circulating tumor cells by reprogramming fatty acid oxidation. Targeting this metabolic vulnerability suppresses metastasis, untangling a key mechanism of breast cancer progression and revealing NNMT as a promising therapeutic target.
Qingchao Tong, Yilei Ma, Yuzhen Gao, Lin Zhou, Luping Lou, Qiang Fang, Sining Fang, Ru Zhao, Jin Zeng, Jun Yang, Guoli Li, Xinyou Xie, Yanzhong Wang, Jun Zhang   +13 more
wiley   +1 more source

Current challenges and the way forwards for regulatory databases of artificial intelligence as a medical device. [PDF]

NPJ Digit Med
Ong AY, Kale AU, Antoun J, Hogg HDJ, Hammond B, Keane PA, Pearson R, Harvey H, Denniston AK.   +8 more
europepmc   +1 more source

Multimodal Wearable Biosensing Meets Multidomain AI: A Pathway to Decentralized Healthcare

Advanced Science, EarlyView.
Multimodal biosensing meets multidomain AI. Wearable biosensors capture complementary biochemical and physiological signals, while cross‐device, population‐aware learning aligns noisy, heterogeneous streams. This Review distills key sensing modalities, fusion and calibration strategies, and privacy‐preserving deployment pathways that transform ...
Chenshu Liu, Haolin Fan, Minwoo Kim, Tong Zhou, Pinyi Yang, Lingdi Zhao, Yiran Wang, Ziyuan Che, Chia‐Wei Liu, Bingbing Li, Yangzhi Zhu   +10 more
wiley   +1 more source

Correction: Cross-Sectional Study on Oral Nicotine Product Sales Trends in Scandinavia From 2018 to 2025.

JMIR Public Health Surveill
Murphy MA, Henenberg D, Reese L.
europepmc   +1 more source

The Institution-based Network on China-Africa Cooperation for Malaria Elimination: fostering a transcontinental hub for strengthening China-Africa cooperation on malaria control and elimination efforts. [PDF]

Infect Dis Poverty
Lu S, Ding W, Huang L, Liu L, Xiao N, Abdulla S, Okpeku M, Thiongane A, Gibba B, Kompaore SCB, Lv S, Li S, Weldedawit MA, Zhou XN, Wang D.   +14 more
europepmc   +1 more source

Proposed Legislation to Amend the Commodity Exchange Act: Hearing Before the H. Comm. on Agriculture, 110th Cong., July 11, 2008 (Statement of Mark D. Young, Adjunct Prof. of Law, Geo. U. L. Center) [PDF]

, 2008
Young, Mark D.
core   +1 more source

Toward Next‐Generation High‐Speed Communication and Imaging: Solution‐Processed Sb2(S,Se)3/CdS Heterojunction for Ultrafast Self‐Powered Photodetector

Advanced Science, EarlyView.
A high‐quality solution‐processed Sb2(S,Se)3/CdS heterojunction is designed to overcome the intrinsic limitations of conventional photodetectors. The fabricated device achieves an excellent self‐powered performance, including a high responsivity of 0.6 A W−1, an ultrahigh specific detectivity of 7.68 × 1012 Jones, and a wide 3db bandwidth of 175 kHz ...
Xuhua Xiao, Yichao Wang, Jingxuan Bian, Hailong Wang, Yongqiang Wang, Jinpeng Xu, Junwei Chen   +6 more
wiley   +1 more source