Results 221 to 230 of about 176,998 (309)

Proceedings from the 2025 Midwest Pediatric Device Consortium showcase featuring software as a medical device. [PDF]

BMC Proc
Echelmeyer N, Noll M, Tandon A, Eckmann DM, Criss CN.   +4 more
europepmc   +1 more source

Heat Shock Protein 90: From Molecular Chaperone Function to Therapeutic Targeting in Malignancies

Advanced Science, EarlyView.
In this review, an integrated conceptual framework linking HSP90's molecular chaperone functions to its pathological roles in cancer is proposed. HSP90 serves as a central node that integrates oncogenic signaling, buffers proteotoxic stress, maintains cancer stem cell plasticity, and shapes tumor‐immune interactions, all of which converge to drive ...
Beibei Zhang, Xinxin Zou, Jiansong Zhou, Qinmiao Sun, Dahua Chen   +4 more
wiley   +1 more source

When BAT Precedes BIG-IV in Infant Botulism: The Need for Structured Antitoxin Decision-Pathway Reporting in Case Reports. [PDF]

Clin Case Rep
Awan MA, Raza HU.
europepmc   +1 more source

PDIA6–SCD1 Axis Rewires Lipid Metabolism to Drive Gastric Cancer Progression

Advanced Science, EarlyView.
Protein disulfide isomerase A6 (PDIA6) is identified as an oncogenic driver in gastric cancer. PDIA6 directly binds and stabilizes SCD1 by limiting its ubiquitin–proteasome‐mediated degradation, thereby sustaining monounsaturated fatty acid (MUFA)‐enriched lipid homeostasis and lipid metabolic reprogramming.
Zhen Tian, Yifan Cheng, Jiajie Zhou, Ruiqi Li, Shuai Zhao, Ben Li, Zijie Xu, Mengli Zi, Yayan Fu, Chenkai Zhang, Qiannan Sun, Shantanu Baral, Sen Wang, Daorong Wang   +13 more
wiley   +1 more source

P04.51. Study of natural health product adverse reactions (SONAR): active surveillance in community pharmacies

BMC Complementary and Alternative Medicine, 2012
Necyk C, Boon H, Foster B, Jaeger W, LeGatt D, Cembrowski G, Murty M, Vu D, Leitch R, Tsuyuki R, Barnes J, Charrois T, Arnason J, Ware M, Rosychuk R, Vohra S   +15 more
doaj   +1 more source

After the green light: Evaluating drugs in Phase IV studies.

Indian J Pharmacol
Meher BR, Mishra A.
europepmc   +1 more source

RNF138‐Mediated Ubiquitination and Degradation of NS5 Restricts Tick‐Borne Encephalitis Virus Infection

Advanced Science, EarlyView.
Host‐specific compatibility between RNF138‐like proteins and flavivirus NS5 determines NS5 stability. Mammalian RNF138 but not arthropod homologs recognizes and induces conserved NS5/RdRp K48‐linked ubiquitination and proteasomal degradation, thereby restricting viral replication. Ectopic RNF138 in mice attenuates TBEV‐induced pathogenesis. (Created in
Jialiang Sun, Weijing Yang, Hao Zhou, Shuai Li, Xin Jiang, Jianyang Gu, Wenyan Zhang   +6 more
wiley   +1 more source

Outpatient step-up dosing of bispecific antibodies in relapsed or refractory multiple myeloma: an oncology nursing framework for monitoring and supportive care. [PDF]

Front Oncol
Song Y, Zhou X, Wang L.
europepmc   +1 more source

Circulating Amino Acid Network Remodeling Reveals Systemic Metabolic Reprogramming Predictive of Colorectal Cancer Recurrence and Metastasis

Advanced Science, EarlyView.
Blood‐based amino acid patterns measured by 19F NMR reveal hidden metabolic changes in colorectal cancer. By analyzing how these amino acids interact as a network, machine learning models identify patients at higher risk of recurrence and metastasis.
Ji‐Yeon Lee, Jumi Kim, Taehan Yoon, So Hyun Kwon, Su Chan Park, Dohyun Chun, Dohyeong Kim, Eun Jung Park, Hyunwoo Kim, Ji Min Lee   +9 more
wiley   +1 more source

Post-marketing surveillance of cordyceps products online: identifying falsified products and regulatory challenges. [PDF]

BMC Complement Med Ther
Wirasathien L, Sriputhon N, Tangkiatkumjai M.   +2 more
europepmc   +1 more source