Results 31 to 40 of about 581,657 (258)

Reform of the Foreign Intelligence Surveillance Courts: Procedural and Operational Changes [PDF]

, 2014
[Excerpt] The Foreign Intelligence Surveillance Act (FISA) of 1978 was the product of sweeping congressional investigation and deliberation prompted by perceived electronic surveillance abuses by the executive branch. Among other things, FISA established
Nolan, Andrew, Thompson, Richard M, II
core   +3 more sources

Policy windows, ambiguity and Commission entrepreneurship: explaining the relaunch of the European Union's economic reform agenda [PDF]

, 2014
This article explains the relaunch of the European Union's (EU) economic reform agenda in 2010. After repeated delays during 2009, the European Commission scaled back its initial plan for a revived social dimension and instead proposed a strengthened ...

core   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Fluoride content of bottled water commercialized in two cities of northeastern Brazil

Brazilian Journal of Oral Sciences, 2015
Aim: The objectives of this study were to evaluate the fluoride content of bottled water commercialized in two cities of northeastern Brazil and to compare the fluoride values measured in the water to the ones printed on the bottle label, considering ...
Consuelo Fernanda Macedo de Souza, Suyene de Oliveira Paredes, Franklin Delano Soares Forte, Fábio Correia Sampaio   +3 more
doaj   +1 more source

The safety assessment of tampons: illustration of a comprehensive approach for four different products

Frontiers in Reproductive Health, 2023
IntroductionWe illustrate a comprehensive tampon safety assessment approach that assures products can be used safely. Material biocompatibility, vaginal mucosa assessment, vaginal microbiome evaluation, and in vitro assessment of potential risk of ...
Anne E. Hochwalt, Joan M. Abbinante-Nissen, Lisa C. Bohman, Anne M. Hattersley, Ping Hu, Jan L. Streicher-Scott, Amber G. Teufel, Kara E. Woeller   +7 more
doaj   +1 more source

Exploring the evidence base for national and regional policy interventions to combat resistance [PDF]

, 2015
The effectiveness of existing policies to control antimicrobial resistance is not yet fully understood. A strengthened evidence base is needed to inform effective policy interventions across countries with different income levels and the human health and
Aarestrup, Aarestrup, Ahuja, Aidara-Kane, Alimuddin Zumla, Allegranzi, Allegranzi, Amábile-Cuevas, Anthony D So, Anthony Kessel, Baertlein, Belongia, Belongia, Bushnell, Catley, Catley, Cheng, Coenen, Crowther-Gibson, Dagan, Datema, Davey, David L Heymann, De Boeck, Earnshaw, Emmeline J Buckley, Fazal K Dar, Finkelstein, Fätkenheuer, Gerber, Govin Permanand, Grave, Grave, Grazia Caleo, Grundmann, Hammerum, Hanne Bak Pedersen, Harbarth, Haydar Giha, Hennessy, Henry Lishi Li, Heuer, Holloway, Huttner, Huttner, Jack, Jasper Littmann, John-Arne Røttingen, Jørgen Schlundt, Kariuki, Katakweba, Khalid M Bindayna, Khan, Komolafe, Kümmerer, Little, Luoto, Mandal, Mark Rweyemamu, Marti, McNulty, Mishal Khan, Mitj, Mohammed Shahid, Moyane, Mshana, Nisi, Ogan, Okeke, Okeke, Okeke, Osman A Dar, Parry, Pittet, Pletz, Radley, Ranji, Richard Kock, Rumina Hasan, Silverman, Simonsen, Song, Speksnijder, Spurling, Stephan Harbarth, Vanden Eng, Vernet, Versporten, Versporten, Viberg, Vlieghe, Walt, Xiao, Zingg   +93 more
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Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Robust Maritime Target Detector in Short Dwell Time

Remote Sensing, 2021
Detection of small-sized maritime targets is an important task for a marine surveillance radar. Recently, with the emergence of a marine surveillance radar system that has a narrow azimuth beamwidth and rapidly rotating antennas, the available dwell time
Myung-Jun Lee, Ji-Eun Kim, Bo-Hyun Ryu, Kyung-Tae Kim   +3 more
doaj   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

How Registries Can Help Performance Measurement Improve Care [PDF]

, 2010
Suggests ways to better utilize databases of clinical information to evaluate care processes and outcomes and improve measurements of healthcare quality and costs, comparative clinical effectiveness research, and medical product safety ...

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