Results 61 to 70 of about 176,998 (309)

Aging Is a Key Driver for Adult Acute Myeloid Leukemia

Aging and Cancer, EarlyView.
Acute myeloid leukemia (AML) is a classical age‐related hematologic malignancy, and a key driver of AML is aging, which profoundly regulates intrinsic factors such as genomic instability, epigenetic reprogramming, and metabolic dysregulation, and alters bone marrow microenvironment.
Rong Yin, Haojian Zhang
wiley   +1 more source

The Structure of Network Administration on the Example of the Organization Market Surveillance Regarding Product Safety in the European Union

, 2023
This article examines how product surveillance actors operate in the EU’s network structure, with a focus on forms of cooperation. Specifically, the study explores coordination systems adopted in market surveillance to demonstrate the network structure’s
Żywicka, Agnieszka, Kokocińska, Katarzyna   +1 more
core   +1 more source

Utilization of in silico-designed primers for SARS-CoV-2 Molecular Surveillance using Direct PCR Product Sequencing Surveillance (DPPSS) Method

Philippine Journal of Pathology
Background. The COVID-19 pandemic caused by SARS-CoV-2 significantly strained healthcare systems in the Philippines, highlighting the critical importance of reliable molecular diagnostics and genomic surveillance. Although vaccination efforts and public
Sarah Jane Datay-Lim, Flyndon Mark Dagalea, Michael Reigh Herrera Guevarra, Kristine Avila, Kim Claudette Fernandez, Francisco Heralde, III   +5 more
doaj   +1 more source

Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance

Aging and Cancer, EarlyView.
NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang, Zhong Fan, Runmeng Liu, Xiaotian Zhang   +3 more
wiley   +1 more source

Clinical Spectrum and Outcomes of SOX1 Antibody‐Associated Paraneoplastic Neurological Syndromes: A Chinese Cohort Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background SOX1 antibody‐positive paraneoplastic neurological syndromes (PNS) exhibit significant population‐specific clinical heterogeneity. While Western cohorts predominantly manifest Lambert‐Eaton myasthenic syndrome (65%–80%), comprehensive clinical characterization and treatment response data in Asian populations remain critically ...
Jin‐Long Ye, Zu‐Ying Kuang, Bo Li, Meng‐Qiu Pan, Li‐Hua Zhou, Yang‐Yang Dai, Si‐Fen Xie, Xian‐Guang Lin, Ye‐Peng Hu, Li‐Hong Jiang, Zhan‐Hang Wang, Wei‐Jing Zhang   +11 more
wiley   +1 more source

Spouse-busting: Intimacy, adultery, and surveillance technology

, 2013
This paper explores emerging practices of intimacy, publicity and privacy evident in online and mobile media applications. It focuses on platforms that facilitate, obscure or reveal adulterous behavior, to understand the surveillance logic underpinning ...
Gregg, Melissa
core  

Societal and ideological impacts of Deep Packet Inspection (DPI) internet surveillance

, 2013
This paper analyses societal and ideological impacts of Deep Packet Inspection (DPI) technologies. DPI surveillance technologies are communications surveillance tools that are able to monitor the traffic of Internet data, including content data.
Fuchs, Christian
core   +1 more source

Cycling infrastructure as a determinant of cycling for recreation and transportation in Montréal, Canada: a natural experiment using the longitudinal national population health survey

International Journal of Behavioral Nutrition and Physical Activity
Background Cycling is associated with numerous health benefits. Evidence suggests that new cycling infrastructure leads to increases in cycling, though studies of network-level changes are lacking.
Stephanie A. Prince, Tyler Thomas, Philippe Apparicio, Lancelot Rodrigue, Christopher Jobson, Kathryn L. Walker, Gregory P. Butler, Rania Wasfi   +7 more
doaj   +1 more source

Impact of Asymptomatic Intracranial Hemorrhage on Outcome After Endovascular Stroke Treatment

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Endovascular treatment (EVT) achieves high rates of recanalization in acute large‐vessel occlusion (LVO) stroke, but functional recovery remains heterogeneous. While symptomatic intracranial hemorrhage (sICH) has been well studied, the prognostic impact of asymptomatic intracranial hemorrhage (aICH) after EVT is less certain ...
Shihai Yang, Chengsong Yue, Zhuang Li, Xiaolei Shi, Haoxuan Zhu, Jie Yang, Linyu Li, Jiaxing Song, Shitao Fan, Gaoming Li, Wenzhe Sun, Zhixian Ye, Jiacheng Huang, Dahong Yang, Jinfu Ma, Xu Xu, Zhixi Wang, Lilan Wang, Guojian Liu, Fengli Li, Changwei Guo, Li Qi, Wenjie Zi   +22 more
wiley   +1 more source

Methods for observational post-licensure medical product safety surveillance

, 2011
Post-licensure medical product safety surveillance is important for detecting adverse events potentially not identified pre-licensure. Historically, post-licensure safety monitoring has been accomplished using passive reporting systems and by conducting
Andrea J Cook, Onchee Yu, Lisa A Jackson, Jennifer C Nelson, Bruce M Psaty, Shanshan Zhao   +5 more
core   +1 more source